MiR-215 modulates gastric cancer cell proliferation by targeting RB1

被引：90

作者：

Deng, Yujie ^{[1
,2
]}

Huang, Zhenxia ^{[3
,4
]}

Xu, Yanjun ^{[1
,2
]}

Jin, Juan ^{[1
,2
]}

Zhuo, Wei ^{[1
,2
,4
]}

Zhang, Cheng ^{[1
,2
]}

Zhang, Xuting ^{[1
,2
]}

Shen, Minhong ^{[1
,2
]}

Yan, Xiaoyi ^{[1
,2
]}

Wang, Liangjing ^{[3
]}

Wang, Xiaojia ^{[5
]}

Kang, Yibin ^{[6
]}

Si, Jianmin ^{[3
,4
]}

Zhou, Tianhua ^{[1
,2
,4
]}

机构：

[1] Zhejiang Univ, Sch Med, Ctr Dis Modeling, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Program Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Clin Res Inst,Gastroenterol Lab, Hangzhou 310016, Zhejiang, Peoples R China

[4] Zhejiang Univ, Inst Gastroenterol, Hangzhou 310016, Zhejiang, Peoples R China

[5] Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

[6] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

CANCER LETTERS | 2014年 / 342卷 / 01期

关键词：

Gastric cancer; MiR-215; Retinoblastoma; Proliferation; DOWN-REGULATION; P53-INDUCIBLE MICRORNAS; MOLECULAR-BIOLOGY; CYCLE ARREST; PROTEIN; RETINOBLASTOMA; EXPRESSION; GENE; CARCINOMA; DIFFERENTIATION;

D O I：

10.1016/j.canlet.2013.08.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 35

页数：9

共 58 条

[1] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[3] The microRNA.org resource: targets and expression [J].

Betel, Doron ;

Wilson, Manda ;

Gabow, Aaron ;

Marks, Debora S. ;

Sander, Chris .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D149-D153

[4] p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins [J].

Boehlig, Levin ;

Friedrich, Maik ;

Engeland, Kurt .

NUCLEIC ACIDS RESEARCH, 2011, 39 (02) :440-453

[5] miR-192/miR-215 Influence 5-Fluorouracil Resistance through Cell Cycle-Mediated Mechanisms Complementary to Its Post-transcriptional Thymidilate Synthase Regulation [J].

Boni, Valentina ;

Bitarte, Nerea ;

Cristobal, Ion ;

Zarate, Ruth ;

Rodriguez, Javier ;

Maiello, Evaristo ;

Garcia-Foncillas, Jesus ;

Bandres, Eva .

MOLECULAR CANCER THERAPEUTICS, 2010, 9 (08) :2265-2275

[6] p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest [J].

Braun, Christian J. ;

Zhang, Xin ;

Savelyeva, Irina ;

Wolff, Sonja ;

Moll, Ute M. ;

Schepeler, Troels ;

Orntoft, Torben F. ;

Andersen, Claus L. ;

Dobbelstein, Matthias .

CANCER RESEARCH, 2008, 68 (24) :10094-10104

[7] Emerging roles of E2Fs in cancer: an exit from cell cycle control [J].

Chen, Hui-Zi ;

Tsai, Shih-Yin ;

Leone, Gustavo .

NATURE REVIEWS CANCER, 2009, 9 (11) :785-797

[8] Expression Levels of MicroRNA-192 and -215 in Gastric Carcinoma [J].

Chiang, Yeunpo ;

Zhou, Xin ;

Wang, Zhenning ;

Song, Yongxi ;

Liu, Zhuangkai ;

Zhao, Fang ;

Zhu, Jinliang ;

Xu, Huimian .

PATHOLOGY & ONCOLOGY RESEARCH, 2012, 18 (03) :585-591

[9] E2f3a and E2f3b Contribute to the Control of Cell Proliferation and Mouse Development [J].

Chong, Jean-Leon ;

Tsai, Shih-Yin ;

Sharma, Nidhi ;

Opavsky, Rene ;

Price, Richard ;

Wu, Lizhao ;

Fernandez, Soledad A. ;

Leone, Gustavo .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (02) :414-424

[10] Rb family proteins in gastric cancer (Review) [J].

Cito, Letizia ;

Pentimalli, Francesca ;

Forte, Iris ;

Mattioli, Eliseo ;

Giordano, Antonio .

ONCOLOGY REPORTS, 2010, 24 (06) :1411-1418

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