EFFECTS OF LOW-INTENSITY PULSED ULTRASOUND FOR PREVENTING JOINT STIFFNESS IN IMMOBILIZED KNEE MODEL IN RATS

被引：18
|
作者：
Itaya, Nobuyuki [1 ]
Yabe, Yutake [1 ]
Hagiwara, Yoshihiro [1 ]
Kanazawa, Kenji [2 ]
Koide, Masashi [3 ]
Sekiguchi, Takuya [1 ]
Yoshida, Shinichirou [1 ]
Sogi, Yasuhito [1 ]
Yano, Toshihisa [1 ]
Tsuchiya, Masahiro [4 ]
Saijo, Yoshihumi [5 ]
Itoi, Eiji [1 ]
机构：
[1] Tohoku Univ, Sch Med, Dept Orthopaed Surg, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan
[2] Iwate Prefectural Cent Hosp, Dept Orthopaed Surg, Morioka, Iwate, Japan
[3] Matsuda Hosp, Dept Orthopaed Surg, Izumi Ku, Sendai, Miyagi, Japan
[4] Tohoku Fukushi Univ, Aoba Ku, Sendai, Miyagi, Japan
[5] Tohoku Univ, Grad Sch Biomed Engn, Dept Biomed Imaging, Aoba Ku, Sendai, Miyagi, Japan
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2018年 / 44卷 / 06期
基金：
日本学术振兴会;
关键词：
Joint immobilization; Low-intensity pulsed ultrasound; LIPUS; Joint stiffness; Joint contracture; Adhesion; Inflammation; Hypoxia; Fibrosis; Elasticity; TISSUE GROWTH-FACTOR; CAPSULE MATRIX TURNOVER; SPINAL-CORD-INJURY; CONNECTIVE-TISSUE; IN-VITRO; CONTRACTURE FORMATION; SYNOVIAL ADHESIONS; COLLAGEN TYPES; RABBIT MODEL; EXPRESSION;
D O I：
10.1016/j.ultrasmedbio.2018.02.002
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) in preventing joint stiffness. Unilateral knee joints were immobilized in two groups of rats (n = 6/period/getup). Under general anesthesia, the immobilized knee joints were exposed to LIPUS for 20 min/d, 5 d/wk, using an existing LIPUS device (LIPUS group, 1.5-MHz frequency, 1.0-kHz repetition cycle, 200-mu s burst width and 30-mW/cm(2) power output) until endpoints (2, 4 or 6 wk). In the control group, general anesthesia alone was administered in the same manner as in the other group. The variables compared between the groups included joint angles; histologic, histomorphometric and immunohistochemical analyses; quantitative reverse transcription polymerase chain reactions; and tissue elasticity. LIPUS had a preventive effect on joint stiffness, resulting in decreased adhesion, fibrosis and inflammation and hypoxic response after joint immobilization. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
引用
收藏
页码：1244 / 1256
页数：13
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