Drug release from lipid liquid crystalline phases: relation with phase behavior

被引：28

作者：

Costa-Balogh, Fatima O. ^{[1
,2
]}

Sparr, Emma ^{[2
]}

Simoes Sousa, Joao Jose ^{[1
]}

Pais, Alberto Canelas ^{[3
]}

机构：

[1] Univ Coimbra, Fac Farm, Lab Galen & Tecnol Farmaceut, Ctr Estudos Farmaceut, P-3000295 Coimbra, Portugal

[2] Lund Univ, Dept Phys Chem 1, Lund, Sweden

[3] Univ Coimbra, Dept Quim, P-3000295 Coimbra, Portugal

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2010年 / 36卷 / 04期

关键词：

Cubic phase; diolein; drug release; monoolein; phytantriol; propranolol hydrochloride; DELIVERY SYSTEMS; CUBIC PHASE; SUSTAINED-RELEASE; IN-VITRO; MONOOLEIN/WATER SYSTEM; WATER SYSTEM; SURFACTANTS; MICROSCOPY; MATRIX; VIVO;

D O I：

10.3109/03639040903261997

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.</.

引用

页码：470 / 481

页数：12

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