Diabetes Mellitus and COVID-19: Associations and Possible Mechanisms

被引：31

作者：

Li, Gerui ^{[1
]}

Chen, Ze ^{[2
]}

Lv, Zhan ^{[1
]}

Li, Hang ^{[1
]}

Chang, Danqi ^{[3
]}

Lu, Jinping ^{[1
]}

机构：

[1] Wuhan Univ, Dept Geratol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

[2] Wuhan Univ, Dept Cardiol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

[3] Wuhan Univ, Dept Geriatr, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2021年 / 2021卷

关键词：

ISLET AUTOIMMUNITY; HOSPITALIZED-PATIENTS; INFECTIONS; RISK; PREVALENCE; CHILDREN; DISEASES; ACE2;

D O I：

10.1155/2021/7394378

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronavirus disease 2019 (COVID-19) is a recently emerged disease with formidable infectivity and high mortality. Emerging data suggest that diabetes is one of the most prevalent comorbidities in patients with COVID-19. Although their causal relationship has not yet been investigated, preexisting diabetes can be considered as a risk factor for the adverse outcomes of COVID-19. Proinflammatory state, attenuation of the innate immune response, possibly increased level of ACE2, along with vascular dysfunction, and prothrombotic state in people with diabetes probably contribute to higher susceptibility for SARS-CoV-2 infection and worsened prognosis. On the other hand, activated inflammation, islet damage induced by virus infection, and treatment with glucocorticoids could, in turn, result in impaired glucose regulation in people with diabetes, thus working as an amplification loop to aggravate the disease. Therefore, glycemic management in people with COVID-19, especially in those with severe illness, is of considerable importance. The insights may help to reduce the fatality in the effort against COVID-19.

引用

页数：10

共 91 条

[1] Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia [J].

Al-Abdely, Hail M. ;

Midgley, Claire M. ;

Alkhamis, Abdulrahim M. ;

Abedi, Glen R. ;

Lu, Xiaoyan ;

Binder, Alison M. ;

Alanazi, Khalid H. ;

Tamin, Azaibi ;

Banjar, Weam M. ;

Lester, Sandra ;

Abdalla, Osman ;

Dahl, Rebecca M. ;

Mohammed, Mutaz ;

Trivedi, Suvang ;

Algarni, Homoud S. ;

Sakthivel, Senthilkumar K. ;

Algwizani, Abdullah ;

Bafaqeeh, Fahad ;

Alzahrani, Abdullah ;

Alsharef, Ali Abraheem ;

Alhakeem, Raafat F. ;

Jokhdar, Hani A. Aziz ;

Ghazal, Sameeh S. ;

Thornburg, Natalie J. ;

Erdman, Dean D. ;

Assiri, Abdullah M. ;

Watson, John T. ;

Gerber, Susan, I .

EMERGING INFECTIOUS DISEASES, 2019, 25 (04) :753-766

[2] Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014 [J].

Alraddadi, Basem M. ;

Watson, John T. ;

Almarashi, Abdulatif ;

Abedi, Glen R. ;

Turkistani, Amal ;

Sadran, Musallam ;

Housa, Abeer ;

Almazroa, Mohammad A. ;

Alraihan, Naif ;

Banjar, Ayman ;

Albalawi, Eman ;

Alhindi, Hanan ;

Choudhry, Abdul Jamil ;

Meiman, Jonathan G. ;

Paczkowski, Magdalena ;

Curns, Aaron ;

Mounts, Anthony ;

Feikin, Daniel R. ;

Marano, Nina ;

Swerdlow, David L. ;

Gerber, Susan I. ;

Hajjeh, Rana ;

Madani, Tariq A. .

EMERGING INFECTIOUS DISEASES, 2016, 22 (01) :49-55

[3] Commentary: COVID-19 and diabetes mellitus: What we know, how our patients should be treated now, and what should happen next [J].

Angelidi, Angeliki M. ;

Belanger, Matthew J. ;

Mantzoros, Christos S. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2020, 107

[4] The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study Rationale and Design [J].

Angus, Derek C. ;

Berry, Scott ;

Lewis, Roger J. ;

Al-Beidh, Farah ;

Arabi, Yaseen ;

van Bentum-Puijk, Wilma ;

Bhimani, Zahra ;

Bonten, Marc ;

Broglio, Kristine ;

Brunkhorst, Frank ;

Cheng, Allen C. ;

Chiche, Jean-Daniel ;

De Jong, Menno ;

Detry, Michelle ;

Goossens, Herman ;

Gordon, Anthony ;

Green, Cameron ;

Higgins, Alisa M. ;

Hullegie, Sebastiaan J. ;

Kruger, Peter ;

Lamontagne, Francois ;

Litton, Edward ;

Marshall, John ;

McGlothlin, Anna ;

McGuinness, Shay ;

Mouncey, Paul ;

Murthy, Srinivas ;

Nichol, Alistair ;

O'Neill, Genevieve K. ;

Parke, Rachael ;

Parker, Jane ;

Rohde, Gernot ;

Rowan, Kathryn ;

Turner, Anne ;

Young, Paul ;

Derde, Lennie ;

McArthur, Colin ;

Webb, Steven A. .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2020, 17 (07) :879-891

[5] Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J].

Assiri, Abdullah ;

Al-Tawfiq, Jaffar A. ;

Al-Rabeeah, Abdullah A. ;

Al-Rabiah, Fahad A. ;

Al-Hajjar, Sami ;

Al-Barrak, Ali ;

Flemban, Hesham ;

Al-Nassir, Wafa N. ;

Balkhy, Hanan H. ;

Al-Hakeem, Rafat F. ;

Makhdoom, Hatem Q. ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

LANCET INFECTIOUS DISEASES, 2013, 13 (09) :752-761

[6] The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes [J].

Bach, Jean-Francois ;

Chatenoud, Lucienne .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (02)

[7] COVID-19-associated vasculitis and vasculopathy [J].

Becker, Richard C. .

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2020, 50 (03) :499-511

[8] Respiratory Infections in Early Life and the Development of Islet Autoimmunity in Children at Increased Type 1 Diabetes Risk Evidence From the BABYDIET Study [J].

Beyerlein, Andreas ;

Wehweck, Fabienne ;

Ziegler, Anette-Gabriele ;

Pflueger, Maren .

JAMA PEDIATRICS, 2013, 167 (09) :800-807

[9] COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow [J].

Bikdeli, Behnood ;

Madhavan, Mahesh V. ;

Jimenez, David ;

Chuich, Taylor ;

Dreyfus, Isaac ;

Driggin, Elissa ;

Der Nigoghossian, Caroline ;

Ageno, Walter ;

Madjid, Mohammad ;

Guo, Yutao ;

Tang, Liang V. ;

Hu, Yu ;

Giri, Jay ;

Cushman, Mary ;

Quere, Isabelle ;

Dimakakos, Evangelos P. ;

Gibson, C. Michael ;

Lippi, Giuseppe ;

Favaloro, Emmanuel J. ;

Fareed, Jawed ;

Caprini, Joseph A. ;

Tafur, Alfonso J. ;

Burton, John R. ;

Francese, Dominic P. ;

Wang, Elizabeth Y. ;

Falanga, Anna ;

McLintock, Claire ;

Hunt, Beverley J. ;

Spyropoulos, Alex C. ;

Barnes, Geoffrey D. ;

Eikelboom, John W. ;

Weinberg, Ido ;

Schulman, Sam ;

Carrier, Marc ;

Piazza, Gregory ;

Beckman, Joshua A. ;

Steg, Gabriel ;

Stone, Gregg W. ;

Rosenkranz, Stephan ;

Goldhaber, Samuel Z. ;

Parikh, Sahil A. ;

Monreal, Manuel ;

Krumholz, Harlan M. ;

Konstantinides, Stavros V. ;

Weitz, Jeffrey I. ;

Lip, Gregory Y. H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (23) :2950-2973

[10] Practical recommendations for the management of diabetes in patients with COVID-19 [J].

Bornstein, Stefan R. ;

Rubino, Francesco ;

Khunti, Kamlesh ;

Mingrone, Geltrude ;

Hopkins, David ;

Birkenfeld, Andreas L. ;

Boehm, Bernhard ;

Amiel, Stephanie ;

Holt, Richard I. G. ;

Skyler, Jay S. ;

DeVries, J. Hans ;

Renard, Eric ;

Eckel, Robert H. ;

Zimmet, Paul ;

George Alberti, Kurt ;

Vidal, Josep ;

Geloneze, Bruno ;

Chan, Juliana C. ;

Ji, Linong ;

Ludwig, Barbara .

LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (06) :546-550

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