Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

被引：29

作者：

Park, Sunyoung ^{[2
]}

Yoon, Sun Young ^{[2
]}

Kim, Kyung-Eun ^{[2
]}

Lee, Ha Reum ^{[2
]}

Hur, Dae Young ^{[3
,4
]}

Song, Hyunkeun ^{[3
,4
]}

Kim, Daejin ^{[5
]}

Bang, Sa Ik ^{[1
]}

Cho, Dae-Ho ^{[2
]}

机构：

[1] Sungkyunkwan Univ, Dept Plast Surg, Sch Med, Samsung Med Ctr, Seoul 135710, South Korea

[2] Sookmyung Womens Univ, Dept Life Sci, Seoul 140742, South Korea

[3] Inje Univ, Busan Paik Hosp, Dept Anat, Pusan, South Korea

[4] Inje Univ, Busan Paik Hosp, Res Ctr Womens Dis, Pusan, South Korea

[5] Chung Ang Univ, Coll Med, Dept Anat, Seoul 156756, South Korea

来源：

CANCER LETTERS | 2009年 / 286卷 / 02期

关键词：

Interleukin-18 (IL-18); Transferrin; Proliferation; Breast cancer; MURINE MELANOMA-CELLS; HUMAN GASTRIC-CANCER; GAMMA PRODUCTION; PATHWAY; IRON; GROWTH; SERUM; PROLIFERATION; CARCINOMA; RECEPTORS;

D O I：

10.1016/j.canlet.2009.05.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：189 / 195

页数：7

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