Meta-analysis of CSF and MRI biomarkers for detecting preclinical Alzheimer's disease

被引:78
作者
Schmand, B. [1 ,2 ]
Huizenga, H. M. [2 ]
van Gool, W. A. [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1100 DD Amsterdam, Netherlands
[2] Univ Amsterdam, Dept Psychol, NL-1100 DD Amsterdam, Netherlands
关键词
Alzheimer's disease; beta-amyloid; cerebrospinal fluid; delayed recall; hippocampus; longitudinal studies; medial temporal lobe; memory; meta-analysis; meta-regression; mild cognitive impairment; MRI; phosphorylated tau; total tau; MILD COGNITIVE IMPAIRMENT; TEMPORAL-LOBE ATROPHY; PHOSPHORYLATED-TAU; PREDICT DEMENTIA; EARLY-DIAGNOSIS; NEUROPSYCHOLOGICAL MARKERS; META-REGRESSION; BRAIN ATROPHY; PROGRESSION; CONVERSION;
D O I
10.1017/S0033291709991516
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. Abnormal levels of biomarkers in cerebrospinal fluid (CSF) and atrophy of medial temporal lobe (MTL) structures on magnetic resonance imaging (MRI) are being used increasingly to diagnose early Alzheimer's disease (AD). We evaluated the claim that these biomarkers can detect preclinical AD before behavioural (i.e. memory) symptoms arise. Method. We included all relevant longitudinal studies of CSF and MRI biomarkers published between January 2003 and November 2008. Subjects were not demented at baseline but some declined to mild cognitive impairment (MCI) or to AD during follow-tip. Measures of tau and beta-amyloid in CSF, MTL atrophy on MRI, and performance on delayed memory tasks were extracted from the papers or obtained from the investigators. Results. Twenty-one MRI studies and 14 CSF Studies were retrieved. The effect sizes of total tau (t-tau), phosphorylated tau (p-tau) and amyloid beta 42 (a beta 42) ranged from 0.91 to 1.11. The effect size of MTL atrophy was 0.75. Memory performance had an effect size of 1.06. MTL atrophy and memory impairment tended to increase when assessed closer to the moment of diagnosis, whereas effect sizes of CSF biomarkers tended to increase when assessed longer before the diagnosis. Conclusions. Memory impairment is a more accurate predictor of early AD than atrophy of MTL on MRI, whereas CSF abnormalities and memory impairment are about equally predictive. Consequently, the CSF and MRI biomarkers are not very sensitive to preclinical AD. CSF markers remain promising, but studies with long follow-up periods in elderly subjects who are normal at baseline are needed to evaluate this promise.
引用
收藏
页码:135 / 145
页数:11
相关论文
共 67 条
[1]   Increasing CSF phospho-tau levels during cognitive decline and progression to dementia [J].
Andersson, Christin ;
Blennow, Kaj ;
Almkvist, Ove ;
Andreasen, Niels ;
Engfeldt, Peter ;
Johansson, Sven-Erik ;
Lindau, Maria ;
Eriksdotter-Jonhagen, Maria .
NEUROBIOLOGY OF AGING, 2008, 29 (10) :1466-1473
[2]   Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal [J].
Apostolova, Liana G. ;
Mosconi, Lisa ;
Thompson, Paul M. ;
Green, Amity E. ;
Hwang, Kristy S. ;
Ramirez, Anthony ;
Mistur, Rachel ;
Tsui, Wai H. ;
de Leon, Mony J. .
NEUROBIOLOGY OF AGING, 2010, 31 (07) :1077-1088
[3]   Cognitive impairment in preclinical Alzheimer's disease:: A meta-analysis [J].
Bäckman, L ;
Jones, S ;
Berger, AK ;
Laukka, EJ ;
Small, BJ .
NEUROPSYCHOLOGY, 2005, 19 (04) :520-531
[4]   Detecting dementia: Novel neuropsychological markers of preclinical Alzheimer's disease [J].
Blackwell, AD ;
Sahakian, BJ ;
Vesey, R ;
Semple, JM ;
Robbins, TW ;
Hodges, JR .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2004, 17 (1-2) :42-48
[5]   CSF markers for incipient Alzheimer's disease [J].
Blennow, K ;
Hampel, H .
LANCET NEUROLOGY, 2003, 2 (10) :605-613
[6]   Towards complete and,accurate reporting of studies of diagnostic accuracy: the STARD initiative [J].
Bossuyt, PM ;
Reitsma, JB ;
Bruns, DE ;
Gatsonis, CA ;
Glasziou, PP ;
Irwig, LM ;
Lijmer, JG ;
Moher, D ;
Rennie, D ;
de Vet, HCE .
BRITISH MEDICAL JOURNAL, 2003, 326 (7379) :41-44
[7]   CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment [J].
Bouwman, F. H. f ;
Schoonenboom, S. N. M. ;
van der Flier, W. M. ;
van Elk, E. J. ;
Kok, A. ;
Barkhof, F. ;
Blankenstein, M. A. ;
Scheltens, Ph .
NEUROBIOLOGY OF AGING, 2007, 28 (07) :1070-1074
[8]   Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment [J].
Brys, Miroslaw ;
Pirraglia, Elizabeth ;
Rich, Kenneth ;
Rolstad, Sindre ;
Mosconi, Lisa ;
Switalski, Remigiusz ;
Glodzik-Sobanska, Lidia ;
De Santi, Susan ;
Zinkowski, Ray ;
Mehta, Pankaj ;
Pratico, Domenico ;
Saint Louis, Leslie A. ;
Wallin, Anders ;
Blennow, Kaj ;
de Leon, Mony J. .
NEUROBIOLOGY OF AGING, 2009, 30 (05) :682-690
[9]   Diagnosis of early dementia by the Double Memory Test: Encoding specificity improves diagnostic sensitivity and specificity [J].
Buschke, H ;
Sliwinski, MJ ;
Kuslansky, G ;
Lipton, RB .
NEUROLOGY, 1997, 48 (04) :989-997
[10]   Trajectories of brain loss in aging and the development of cognitive impairment [J].
Carlson, N. E. ;
Moore, M. M. ;
Dame, A. ;
Howieson, D. ;
Silbert, L. C. ;
Quinn, J. F. ;
Kaye, J. A. .
NEUROLOGY, 2008, 70 (11) :828-833