Batch and Continuous-Flow Iron(II)-Catalyzed Synthesis of Sulfilimines and Sulfoximines using N-Mesyloxycarbamates

被引：20
作者：
Lai, Calvine [1 ,2 ]
Mathieu, Gary [1 ,2 ]
Tabarez, Lucia Paola Gabrielli [1 ,2 ]
Lebel, Helene [1 ,2 ]
机构：
[1] Univ Montreal, Dept Chem, POB 6128, Montreal, PQ H3C 3J7, Canada
[2] Univ Montreal, CGCC, POB 6128, Montreal, PQ H3C 3J7, Canada
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 40期
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
amination; continuous flow; iron; nitrene; sulfilimines; CATALYZED NITRENE TRANSFER; SULFUR IMIDATIONS; IONIC LIQUIDS; SULFOXIDES; SULFIDES; IMINATION; AZIDE; SULFIMIDATION; AMINATION; CHEMISTRY;
D O I：
10.1002/chem.201900953
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of sulfilimines and sulfoximines with N-mesyloxycarbamates in presence of catalytic iron(II) chloride hydrate is described. The use of 1-butylimidazole as a base proved instrumental in enabling a homogeneous reaction mixture compatible with continuous flow processes. The amination is applicable to a wide range of substrates, and affords the desired product in good to excellent yields within 1 to 60 minutes.
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页码：9423 / 9426
页数：4
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