From rabbit antibody repertoires to rabbit monoclonal antibodies

被引：112

作者：

Weber, Justus ^{[1
]}

Peng, Haiyong ^{[1
]}

Rader, Christoph ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbiol, Jupiter, FL 33458 USA

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2017年 / 49卷

关键词：

V-H GENES; INTERDOMAIN DISULFIDE BOND; SINGLE-CHAIN ANTIBODIES; PHAGE DISPLAY APPROACH; B-CELL; LIGHT-CHAIN; TUMOR-GROWTH; PROGESTERONE-RECEPTOR; BREAST-CANCER; RESTRICTED UTILIZATION;

D O I：

10.1038/emm.2017.23

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the unique ontogeny of rabbit B cells that affords highly distinctive antibody repertoires rich in in vivo pruned binders of high diversity, affinity and specificity, we describe the generation of rabbit monoclonal antibodies by hybridoma technology, phage display and alternative methods, along with an account of successful humanization strategies.

引用

页码：e305 / e305

页数：12

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