Generalized Augmentation to Control the False Discovery Exceedance in Multiple Testing

被引：7
作者：
Farcomeni, Alessio [1 ]
机构：
[1] Univ Roma La Sapienza, I-00185 Rome, Italy
来源：
SCANDINAVIAN JOURNAL OF STATISTICS | 2009年 / 36卷 / 03期
关键词：
dependence; DNA microarrays; false discovery exceedance; false discovery rate; family-wise error rate; multiple testing; NUMBER; HYPOTHESES; PROPORTION; VARIANCE; HEALTH;
D O I：
10.1111/j.1467-9469.2008.00633.x
中图分类号：
O21 [概率论与数理统计]; C8 [统计学];
学科分类号：
020208 ; 070103 ; 0714 ;
摘要：
A new multiple testing procedure, the generalized augmentation procedure (GAUGE), is introduced. The procedure is shown to control the false discovery exceedance and to be competitive in terms of power. It is also shown how to apply the idea of GAUGE to achieve control of other error measures. Extensions to dependence are discussed, together with a modification valid under arbitrary dependence. We present an application to an original study on prostate cancer and on a benchmark data set on colon cancer.
引用
收藏
页码：501 / 517
页数：17
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