Bovine herpesvirus type 5 replication and induction of apoptosis in vitro and in the trigeminal ganglion of experimentally-infected cattle

被引：13

作者：

Rensetti, Daniel E. ^{[1
]}

Marin, Maia S. ^{[2
,3
]}

Moran, Pedro E. ^{[1
]}

Odeon, Anselmo C. ^{[3
]}

Verna, Andrea E. ^{[2
,3
]}

Perez, Sandra E. ^{[4
]}

机构：

[1] Univ Nacl Ctr Provincia Buenos Aires, Fac Ciencias Vet, Paraje Arroyo Seco S-N, RA-7000 Tandil, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Rivadavia 1917,C1033AAJ, Buenos Aires, DF, Argentina

[3] Estn Expt Agr Balcarce, INTA, Ruta 226 Km 73-5, RA-7620 Balcarce, Buenos Aires, Argentina

[4] Univ Nacl Ctr Provincia Buenos Aires, CONICET, Fac Ciencias Vet, Ctr Invest Vet Tandil CIVETAN, Paraje Arroyo Seco S-N, RA-7000 Tandil, Argentina

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2018年 / 57卷

关键词：

Apoptosis; Bovine herpesvirus 1 and 5; Trigeminal ganglion; Neuropathogenesis; LATENCY-RELATED GENE; CENTRAL-NERVOUS-SYSTEM; PATHOGENESIS; REACTIVATION; EXPRESSION; NEURONS; ENCEPHALITIS; RECOGNITION; BHV-1;

D O I：

10.1016/j.cimid.2018.01.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bovine herpesvirus (BoHV) types 1 and 5 are neuroinvasive. Cases of BoHV-1-induced encephalitis are not as frequent as those caused by BoHV-5. In this study, the capability of BoHV-5 to induce apoptosis in cell cultures and in the trigeminal ganglion during acute infection of experimentally-infected cattle was analyzed. Apoptotic changes in cell cultures agree with the ability of the viral strains to replicate in each cell line. Marked differences were observed between the in vitro induction of apoptosis by BoHV-1Cooper and BoHV-5 97/613 strains. Apoptotic neurons were clearly evident in the trigeminal ganglion of BoHV-1-infected calves. For BoHV-5 a fewer number of positive neurons was observed. There is an association between the magnitude of bovine herpesviruses replication and the induction of apoptosis in trigeminal ganglion. These findings suggest that the induction of apoptosis and the innate immune response orchestrate the final outcome of alpha herpesviruses infection of the bovine nervous system.

引用

页码：8 / 14

页数：7

共 34 条

[1] Pathogen recognition and innate immunity [J].