Synthesis and living cell imaging of a novel fluorescent sensor for selective cupric detection

被引：5

作者：

Luo, Qianping ^{[1
]}

Bandi, Koteswara Rao ^{[2
]}

Dong, Yanqiu ^{[1
]}

Bao, Hongli ^{[2
]}

Li, Daliang ^{[1
,3
]}

Chen, Qi ^{[1
]}

机构：

[1] Fujian Normal Univ, Coll Life Sci, Biomed Res Ctr South China, Key Lab Innate Immune Biol Fujian Prov, 1 Keji Rd, Fuzhou 350117, Fujian, Peoples R China

[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, 155 Yangqiao Rd West, Fuzhou 350002, Fujian, Peoples R China

[3] Fujian Normal Univ, Ctr Engn Technol Res Microalgae Germplasm Improve, Southern Inst Oceanog, Publ Serv Platform Industrializat Dev Technol Mar, Fuzhou 350117, Fujian, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2019年 / 214卷

关键词：

Fluorescent spectroscopy; Cu(II); Absorption spectroscopy; Living cell imaging; COPPER COORDINATION; METAL-IONS; ALZHEIMERS; PARKINSONS; IRON; CHEMOSENSORS; CHEMISTRY; PROBES; ZINC;

D O I：

10.1016/j.saa.2019.02.013

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Copper is an important element indispensable for human life and health. Many copper-determining probes have been created for exploring its functional behavior in various cell types but few of them contains both fluorescent and colorimetric characters. In the present study, we developed a set of copper probes by synthesizing several novel thiophene-based Schiff bases in order to make a suitable sensor for quantifying and imaging copper in living cells. We find that the ligand FS-1 has a splendid selectivity and affinity toward Cu2+ among the common divalent metal ions. Living cell imaging show that FS-1 has a robust and repetitive fluorescence response in the presence of Cu2+ only in the cytosolic space of Hepg2 cell and not in the other cells examined. These data suggest that we have developed a new copper probe that can be used as a Cu2+ fluorescent and colorimetric sensor for in vivo and in vitro copper studies. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：146 / 151

页数：6

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