One Stone, Three Birds: pH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization

被引：99

作者：

Song, Yan ^{[1
]}

Zhang, Hongxing ^{[2
]}

Wang, Xia ^{[3
]}

Geng, Xin ^{[1
]}

Sun, Yuanqiang ^{[1
]}

Liu, Jing ^{[2
]}

Li, Zhaohui ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Henan Joint Int Res Lab Green Construct Funct Mol, Zhengzhou 450001, Peoples R China

[2] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Peoples R China

[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2021年 / 93卷 / 03期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

FLUORESCENT-PROBE; DESIGN; SENSOR; DYES;

D O I：

10.1021/acs.analchem.0c04644

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The lysosomes of cancer cells have lower pH and higher viscosity than those of normal cells. These features can be used as sensitive and selective markers for cancer diagnosis. In this work, a pH and viscosity dual responsive lysosome targeting fluorescent probe 1 was designed based on the transformation of amino- and imino- forms of pyronine and the twisted intramolecular charge shuttle (TICS) sensing mechanism. Live cancer cells and tumors were effectively distinguished from normal cells and organs through fluorescence imaging of probe 1, which indicated that probe 1 could serve as an effective tool for visualization of tumors at organ level with high selectivity.

引用

页码：1786 / 1791

页数：6

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