Palladium-Catalyzed Decarboxylative Acylation of N-Nitrosoanilines with α-Oxocarboxylic Acids

被引：58

作者：

Wu, Yinuo ^{[1
]}

Sun, Lei ^{[1
]}

Chen, Yunyun ^{[1
]}

Zhou, Qian ^{[1
]}

Huang, Jia-Wu ^{[1
]}

Miao, Hui ^{[1
]}

Luo, Hai-Bin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 03期

基金：

中国国家自然科学基金;

关键词：

DECARBONYLATIVE HECK OLEFINATION; H BOND ACYLATION; TOLUENE DERIVATIVES; BENZOPHENONES; ACETANILIDES; ACTIVATION; INDOLES; BIARYLS; ACCESS; ESTERS;

D O I：

10.1021/acs.joc.5b02535

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed oxidative C-H bond decarboxylative acylation of N-nitrosoanilines using alpha-oxocarboxylic acid as the acyl source is described. The catalyst Pd(OAc)(2) and oxidant (NH4)(2)S2O8 enabled ortho-acylation of N-nitrosoanilines at room temperature, affording an array of N-nitroso-2-aminobenzophenones in moderate to excellent yields.

引用

页码：1244 / 1250

页数：7

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