Palladium-Catalyzed Decarboxylative Acylation of N-Nitrosoanilines with α-Oxocarboxylic Acids

被引：58
|
作者：
Wu, Yinuo [1 ]
Sun, Lei [1 ]
Chen, Yunyun [1 ]
Zhou, Qian [1 ]
Huang, Jia-Wu [1 ]
Miao, Hui [1 ]
Luo, Hai-Bin [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 03期
基金：
中国国家自然科学基金;
关键词：
DECARBONYLATIVE HECK OLEFINATION; H BOND ACYLATION; TOLUENE DERIVATIVES; BENZOPHENONES; ACETANILIDES; ACTIVATION; INDOLES; BIARYLS; ACCESS; ESTERS;
D O I：
10.1021/acs.joc.5b02535
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed oxidative C-H bond decarboxylative acylation of N-nitrosoanilines using alpha-oxocarboxylic acid as the acyl source is described. The catalyst Pd(OAc)(2) and oxidant (NH4)(2)S2O8 enabled ortho-acylation of N-nitrosoanilines at room temperature, affording an array of N-nitroso-2-aminobenzophenones in moderate to excellent yields.
引用
收藏
页码：1244 / 1250
页数：7
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