Outcomes and Prognostic Factors Following Surgical Treatment of Pulmonary Metastases from Colorectal Carcinoma

被引：0
|
作者：
Vodicka, Josef [1 ]
Fichtl, Jakub [1 ]
Sebek, Jakub [1 ]
Prochazkova, Kristyna [1 ]
Skala, Martin [1 ]
Treska, Vladislav [1 ]
Kormunda, Stanislav [1 ]
Vankova, Bohuslava [2 ]
Svaton, Martin [3 ]
Topolcan, Ondrej [4 ]
Kucera, Radek [4 ]
机构：
[1] Charles Univ Prague, Univ Hosp Pilsen, Fac Med Pilsen, Dept Surg, Plzen, Czech Republic
[2] Charles Univ Prague, Univ Hosp Pilsen, Fac Med Pilsen, Dept Pathol, Plzen, Czech Republic
[3] Charles Univ Prague, Univ Hosp Pilsen, Fac Med Pilsen, Dept Pneumol & Phtisiol, Plzen, Czech Republic
[4] Charles Univ Prague, Univ Hosp Pilsen, Fac Med Pilsen, Dept Immunochem Diagnost, Plzen, Czech Republic
来源：
ANTICANCER RESEARCH | 2020年 / 40卷 / 12期
关键词：
Lung cancer; pulmonary metastases; colorectal carcinoma; surgery; biomarker; prognosis; LUNG METASTASECTOMY; RISK-FACTORS; CANCER; RESECTION; SURVIVAL; IMPACT;
D O I：
10.21873/anticanres.14731
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: The lungs are the second most common site of cancer dissemination. The aim of this study was to analyze a cohort of patients operated for pulmonary metastases from colorectal carcinoma over a period of 18 years. Patients and Methods: In a group of 104 patients, relations were sought between overall survival or disease free survival and preoperative levels of selected biomarkers, number of metastases and the condition of the intrathoracic lymphatic nodes. Median observation period was 63 months. Results: The 5-year survival rate was 54.3%. Risk of disease progression and risk of death increases in case of occurrence of 2 or more metastases, affection of intrathoracic lymph nodes and levels of CA 19-9, TPS or CEA above cut-off value. Conclusion: Prognostic factors that determine overall survival as well as disease-free survival are the number of metastases, the condition of intrathoracic lymphatic nodes and the preoperative levels of biomarkers.
引用
收藏
页码：7045 / 7051
页数：7
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