Synthesis of Novel 6-(Substituted benzyl)imidazo[2,1-b][1,3]thiazole Catalyzed by Polystyrene-Supported Palladium(II) Ethylenediamine Complex

被引：14

作者：

Bakherad, Mohammad ^{[1
]}

Keivanloo, Ali ^{[1
]}

Bahramian, Bahram ^{[1
]}

Kamali, Taghi A. ^{[1
]}

机构：

[1] Shahrood Univ Technol, Fac Chem, Shahrood, Iran

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2009年 / 20卷 / 05期

关键词：

Sonogashira coupling; heterogeneous catalyst; aryl iodides; imidazothiazoles; SONOGASHIRA COUPLING REACTION; POTENTIAL ANTITUMOR AGENTS; ARYL HALIDES; RECYCLABLE CATALYST; TERMINAL ALKYNES; EFFICIENT; ACETYLENES; BROMIDES; HECK;

D O I：

10.1590/S0103-50532009000500015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The polymer-supported palladium(II) ethylenediamine complex, [PS-en-Pd(II)], is a highly active catalyst that could be used for the Sonogashira coupling reaction between an aryl iodide and 2-amino-3-(2-propynyl)-1,3-thiazolium bromide, 3. This heterogeneous palladium catalyst is efficient, stable, and recyclable. Reaction of compound 3 with various aryl iodides, 4a-f in the presence of the [PS-en-Pd( II)] complex leads to the production of the 6-(substituted benzyl) imidazo[2,1-b][1,3] thiazoles 5a-f.

引用

页码：907 / 912

页数：6

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