Synthesis of Novel 2-Amino-substituted 6-Methyl-pyrimidin-4-ol Derivatives and Their Biological Evaluation

被引：0

作者：

Yengoyan, Aleksandr P. ^{[1
]}

Pivazyan, Vergush A. ^{[2
]}

Ghazaryan, Emma A. ^{[2
]}

Azaryan, Zhermen A. ^{[1
]}

机构：

[1] Russian Armenian Univ, H Emin Str 123, Yerevan 0051, Armenia

[2] Natl Agr Univ Armenia, Teryan Str 74, Yerevan 0009, Armenia

来源：

LETTERS IN ORGANIC CHEMISTRY | 2019年 / 16卷 / 07期

关键词：

O-Substituted; 2-amino-4-methylpyrimidin-4-ols; 4-triazolylaminopyrimidines; heterocyclization; 1,3,4-oxadiazolyl-alkyloxypyrimidines; plant growth stimulant activity; heteroauxin; IN-VITRO ANTIBACTERIAL; PYRIMIDINE-DERIVATIVES; ANTIOXIDANT; ANALOGS; DESIGN;

D O I：

10.2174/1570178615666181025120951

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel derivatives based on 2-amino-substituted 4-methylpyrimidin-4-ols were synthesized by simple, accessible and efficient methods. 4-N-triazolyl derivatives were obtained from the corresponding 4-chloro derivatives, and O-substituted products, including compounds with a combination of the pyrimidine and oxadiazole rings in the molecule, were synthesized from the sodium salts of 2-amino-substituted pyrimidin-4-ols. The synthesized compounds showed a pronounced stimulating action on plants growth. Their growth stimulant activities were in the range of 46-93% compared to heteroauxin.

引用

页码：575 / 583

页数：9

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