Prevalence of CD30 immunostaining in neoplastic mast cells: A retrospective immunohistochemical study

被引:15
作者
de Paiva Silva, Geisilene Russano [1 ,5 ]
Tournier, Emilie [1 ,2 ]
Sarian, Luis Otavio [5 ]
Bulai-Livideanu, Cristina [3 ,4 ]
Delsol, Georges [1 ,2 ]
Lamant, Laurence [1 ,2 ]
Vassallo, Jose [5 ]
Brousset, Pierre [1 ,2 ,6 ]
Laurent, Camille [1 ,2 ,6 ]
机构
[1] Univ Paul Sabatier, Ctr Rech Canc Toulouse, UMR U 1037, Toulouse, France
[2] Inst Univ Canc Toulouse Oncopole, Dept Pathol, Toulouse, France
[3] Toulouse Univ, Paul Sabatier Univ, Mastocytosis Natl Reference Ctr CEREMAST, Dept Dermatol, Toulouse, France
[4] CHU, Toulouse, France
[5] Univ Estadual Campinas, Med Sch, Fac Med Sci, Lab Mol & Invest Pathol LAPE, Campinas, SP, Brazil
[6] Lab Excellence Labex TOUCAN, Toulouse, France
关键词
CD30; cutaneous mastocytosis; immunohistochemistry; mastocytosis; SYSTEMIC MASTOCYTOSIS; HODGKINS-DISEASE;
D O I
10.1097/MD.0000000000010642
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mastocytosis is a rare disease characterized by clonal neoplastic proliferation of mast cells (MCs). It ranges from skin lesions as cutaneous mastocytosis (CM) which may spontaneously regress to highly aggressive neoplasms with multiorgan involvement corresponding to some aggressive systemic mastocytosis (ASM), mast cell leukemia (MCL), and/or mast cell sarcoma (MCS).There is increasing evidence of CD30 expression in neoplastic MCs of the bone marrow. This expression has been described almost exclusively in aggressive forms of systemic mastocytosis (SM).The aim of the present study is to evaluate CD30 expression both in cutaneous and systemic forms of mastocytosis. Forty-two mastocytosis cases were reviewed, including cutaneous (n=29) and systemic (n=13) forms to assess the prevalence of CD30 expression. Thirty-nine out of 42 (92.8%) cases were CD30 positive. In cases of CM, 28/29 (96.5%) cases were CD30 positive, 11/13 cases of SM (84.6%) were positive for CD30. MCs in normal skin biopsies and in urticaria lesions were CD30-negative. This study found that CD30 is also frequently expressed in CM as well as in systemic forms. This finding is a major departure from the prevailing concept that CD30 expression is often related to aggressive systemic forms of mastocytosis.
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页数:5
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