Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

被引：74

作者：

Schneider, Anja

Schulz-Schaeffer, Walter

Hartmann, Tobias

Schulz, Joerg B.

Simons, Mikael

机构：

[1] Univ Gottingen, Ctr Biochem & Mol Cell Biol, D-37073 Gottingen, Germany

[2] Univ Gottingen, Dept Neuropathol, D-37099 Gottingen, Germany

[3] Ctr Mol Biol, D-69120 Heidelberg, Germany

[4] Ctr Neurol Med, Dept Neurodegenerat & Restorat Res, D-37073 Gottingen, Germany

[5] Ctr Neurol Med, CMPB, D-37073 Gottingen, Germany

来源：

NEUROBIOLOGY OF DISEASE | 2006年 / 23卷 / 03期

关键词：

cholesterol; aggregation; hippocampal neurons; A beta; oligomers; Alzheimer's disease;

D O I：

10.1016/j.nbd.2006.04.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid A beta-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble A beta. We found that reduction of neuronal cholesterol by similar to 25% reduced the neuronal formation of insoluble A beta without affecting the secretion of soluble A beta. Moreover, we demonstrate that A beta-oligomers from Alzheimer's disease brains associate with a detergent-resistant membrane fraction in a cholesterol-dependent manner. These results suggest a key role for cholesterol in aggregation of A beta. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：573 / 577

页数：5

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