Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d

被引：37

作者：

Dal Bo, Michele ^{[1
]}

Tissino, Erika ^{[1
]}

Benedetti, Dania ^{[1
]}

Caldana, Chiara ^{[1
]}

Bomben, Riccardo ^{[1
]}

Del Poeta, Giovanni ^{[2
,3
]}

Gaidano, Gianluca ^{[4
]}

Rossi, Francesca Maria ^{[1
]}

Zucchetto, Antonella ^{[1
]}

Gattei, Valter ^{[1
]}

机构：

[1] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, I-33081 Aviano, PN, Italy

[2] S Eugenio Hosp, Div Hematol, Rome, Italy

[3] Univ Roma Tor Vergata, Rome, Italy

[4] Amedeo Avogadro Univ Eastern Piedmont, Dept Clin & Expt Med, Div Hematol, Novara, Italy

来源：

SEMINARS IN HEMATOLOGY | 2014年 / 51卷 / 03期

关键词：

B-CELL RECEPTOR; TYROSINE KINASE INHIBITOR; IN-SITU HYBRIDIZATION; MARROW STROMAL CELLS; BONE-MARROW; ALPHA-4-BETA-1; INTEGRIN; ANTIGEN-RECEPTOR; LYMPH-NODES; SPONTANEOUS APOPTOSIS; DEPENDENT REGULATION;

D O I：

10.1053/j.seminhematol.2014.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：168 / 176

页数：9

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