Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d

被引：37

作者：

Dal Bo, Michele ^{[1
]}

Tissino, Erika ^{[1
]}

Benedetti, Dania ^{[1
]}

Caldana, Chiara ^{[1
]}

Bomben, Riccardo ^{[1
]}

Del Poeta, Giovanni ^{[2
,3
]}

Gaidano, Gianluca ^{[4
]}

Rossi, Francesca Maria ^{[1
]}

Zucchetto, Antonella ^{[1
]}

Gattei, Valter ^{[1
]}

机构：

[1] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, I-33081 Aviano, PN, Italy

[2] S Eugenio Hosp, Div Hematol, Rome, Italy

[3] Univ Roma Tor Vergata, Rome, Italy

[4] Amedeo Avogadro Univ Eastern Piedmont, Dept Clin & Expt Med, Div Hematol, Novara, Italy

来源：

SEMINARS IN HEMATOLOGY | 2014年 / 51卷 / 03期

关键词：

B-CELL RECEPTOR; TYROSINE KINASE INHIBITOR; IN-SITU HYBRIDIZATION; MARROW STROMAL CELLS; BONE-MARROW; ALPHA-4-BETA-1; INTEGRIN; ANTIGEN-RECEPTOR; LYMPH-NODES; SPONTANEOUS APOPTOSIS; DEPENDENT REGULATION;

D O I：

10.1053/j.seminhematol.2014.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：168 / 176

页数：9

共 96 条

[11]

Burger JA, 2000, BLOOD, V96, P2655

[12] The microenvironment in mature B-cell malignancies: a target for new treatment strategies [J].

Burger, Jan A. ;

Ghia, Paolo ;

Rosenwald, Andreas ;

Caligaris-Cappio, Federico .

BLOOD, 2009, 114 (16) :3367-3375

[13] High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation [J].

Burger, Jan A. ;

Quiroga, Maite P. ;

Hartmann, Elena ;

Buerkle, Andrea ;

Wierda, William G. ;

Keating, Michael J. ;

Rosenwald, Andreas .

BLOOD, 2009, 113 (13) :3050-3058

[14] Vav proteins, adaptors and cell signaling [J].

Bustelo, XR .

ONCOGENE, 2001, 20 (44) :6372-6381

[15] Role of the microenvironment in chronic lymphocytic leukaemia [J].

Caligaris-Cappio, F .

BRITISH JOURNAL OF HAEMATOLOGY, 2003, 123 (03) :380-388

[16] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[17] Intraclonal Complexity in Chronic Lymphocytic Leukemia: Fractions Enriched in Recently Born/Divided and Older/Quiescent Cells [J].

Calissano, Carlo ;

Damle, Rajendra N. ;

Marsilio, Sonia ;

Yan, Xiao-Jie ;

Yancopoulos, Sophia ;

Hayes, Gregory ;

Emson, Claire ;

Murphy, Elizabeth J. ;

Hellerstein, Marc K. ;

Sison, Cristina ;

Kaufman, Matthew S. ;

Kolitz, Jonathan E. ;

Allen, Steven L. ;

Rai, Kanti R. ;

Ivanovic, Ivana ;

Dozmorov, Igor M. ;

Roa, Sergio ;

Scharff, Matthew D. ;

Li, Wentian ;

Chiorazzi, Nicholas .

MOLECULAR MEDICINE, 2011, 17 (11-12) :1374-1382

[18] B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor [J].

Chiorazzi, N ;

Ferrarini, M .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :841-894

[19] Mechanisms of disease: Chronic lymphocytic leukemia [J].

Chiorazzi, N ;

Rai, KR ;

Ferrarini, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :804-815

[20] Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities [J].

Chiorazzi, Nicholas ;

Ferrarini, Manlio .

BLOOD, 2011, 117 (06) :1781-1791

← 1 2 3 4 5 6 7 8 9 10 →