In Vitro Characterization of a Sustained-Release Formulation for Enfuvirtide

被引：10
|
作者：
Rothstein, Sam N. [1 ]
Huber, Kelly D. [2 ]
Siuis-Cremer, Nicolas [2 ]
Little, Steven R. [1 ,3 ,4 ,5 ,6 ]
机构：
[1] Qrono Inc, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Chem Engn, Pittsburgh, PA 15261 USA
[4] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA
[5] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA
[6] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 03期
关键词：
ERODING POLYMER MATRICES; PREDICTION; HIV-1; MODEL;
D O I：
10.1128/AAC.02440-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Although approved by the U.S. Food and Drug Administration, enfuvirtide is rarely used in combination antiretroviral therapies (cART) to treat HIV-1 infection, primarily because of its intense dosing schedule that requires twice-daily subcutaneous injection. Here, we describe the development of enfuvirtide-loaded, degradable poly(lactic-co-glycolic) acid microparticles that provide linear in vitro release of the drug over an 18-day period. This sustained-release formulation could make enfuvirtide more attractive for use in cART.
引用
收藏
页码：1797 / 1799
页数：3
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