Catalytic Intermolecular Aldehyde-Ketone Coupling via Acyl Phosphonates

被引：54

作者：

Demir, Ayhan S. ^{[1
]}

Esiringue, Iker ^{[1
]}

Gollu, Mehmet ^{[1
]}

Reis, Oemer ^{[1
]}

机构：

[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 05期

关键词：

NUCLEOPHILIC ACYLATION; ANION EQUIVALENTS; BENZOIN REACTIONS; ACYLPHOSPHONATES; REARRANGEMENT; DONOR;

D O I：

10.1021/jo8026627

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first catalytic intermolecular aldehyde-ketone coupling via acyl phosphonate is reported. Acyl phosphonates are potent acyl anion precursors, which generate acyl anion equivalents under the influence of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with activated ketones to form acyloin type coupling in 41-95% yields.

引用

页码：2197 / 2199

页数：3

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