Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study

被引：98

作者：

Gibson, Peter R. ^{[1
,2
]}

Vaizey, Carolynne ^{[3
]}

Black, Christopher M. ^{[4
,5
]}

Nicholls, Rebecca ^{[6
]}

Weston, Adele R. ^{[6
]}

Bampton, Peter ^{[7
]}

Sparrow, Miles ^{[1
]}

Lawrance, Ian C. ^{[8
]}

Selby, Warwick S. ^{[9
,10
]}

Andrews, Jane M. ^{[11
,12
]}

Walsh, Alissa J. ^{[13
]}

Hetzel, David J. ^{[14
]}

Macrae, Finlay A. ^{[15
]}

Moore, Gregory T. ^{[2
,16
]}

Weltman, Martin D. ^{[17
]}

Leong, Rupert W. ^{[18
]}

Fan, Tao ^{[5
]}

机构：

[1] Alfred Hosp, Melbourne, Vic 3004, Australia

[2] Monash Univ, Clayton, Vic, Australia

[3] St Marks Hosp, London EC1V 2PS, England

[4] St Johns Univ, Queens, NY USA

[5] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA

[6] OptumInsight, Sydney, NSW, Australia

[7] Flinders Private Hosp, Bedford Pk, SA, Australia

[8] Univ Western Australia, Sch Med & Pharmacol, Ctr Inflammatory Bowel Dis, Fremantle Hosp, Fremantle, WA, Australia

[9] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia

[10] Univ Sydney, Sydney, NSW 2006, Australia

[11] Royal Adelaide Hosp, Dept Gastroenterol & Hepatol, IBD Serv, Adelaide, SA 5000, Australia

[12] Univ Adelaide, Sch Med, Adelaide, SA, Australia

[13] St Vincents Hosp, Sydney, NSW 2010, Australia

[14] East Adelaide Med Ctr, Adelaide, SA, Australia

[15] Royal Melbourne Hosp, Parkville, Vic 3050, Australia

[16] Monash Med Ctr, Clayton, Vic 3168, Australia

[17] Univ Sydney, Nepean Hosp, Sydney, NSW 2006, Australia

[18] Concord Hosp, Sydney, NSW, Australia

来源：

JOURNAL OF CROHNS & COLITIS | 2014年 / 8卷 / 07期

关键词：

Ulcerative colitis; Health care utilization; Disease severity; Quality of life; Utility; INFLAMMATORY-BOWEL-DISEASE; NATIONAL-SURVEY; CROHNS-DISEASE; PREVALENCE; INSTRUMENT; VALIDITY; UTILITY; EQ-5D;

D O I：

10.1016/j.crohns.2013.11.017

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & aims: The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps < 0.001). IBDQ correlated with both AQoL-8D (r = 0.73; P < 0.0001) and EQ-5D-5L (0.69; P < 0.0001). Mean 3-month UC-related health care cost per patient was AUD $2914 (SD = $3447 [mean for patients in remission = $1970; mild disease = $3736; moderate/severe disease = $4162]). Patients in remission had the least work and activity impairment. Conclusions: More severe UC disease was associated with poorer QoL. Substantial health care utilization, costs, and work productivity impairments were found in this sample of patients with UC. Moreover, greater disease activity was associated with greater health care costs and impairment in work productivity and daily activities. (C) 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

引用

页码：598 / 606

页数：9

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