Biodegradable polymeric nanoparticles based on amphiphilic principle: construction and application in drug delivery

被引：52
|
作者：
Zhang ShiYong [1 ]
Wu Yao [1 ]
He Bin [1 ]
Luo Kui [1 ]
Gu ZhongWei [1 ]
机构：
[1] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2014年 / 57卷 / 04期
基金：
中国国家自然科学基金;
关键词：
biodegradable polymer; micelle; amphiphilicity; drug-delivery system; cancer; BLOCK-COPOLYMER MICELLES; IN-VITRO; POLY(ETHYLENE GLYCOL); ANTICANCER DRUGS; CONTROLLED-RELEASE; EXTRACELLULAR PH; CANCER-THERAPY; RADICAL POLYMERIZATION; MULTIBLOCK COPOLYMERS; N-CARBOXYANHYDRIDES;
D O I：
10.1007/s11426-014-5076-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The use of nanotechnology in drug-delivery systems (DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.
引用
收藏
页码：461 / 475
页数：15
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