A low-cost automated flow analyzer based on low temperature co-fired ceramic and LED photometer for ascorbic acid determination

被引：9
作者：
Pessoa-Neto, Osmundo D. [1 ]
dos Santos, Vagner B. [1 ]
Vicentini, Fernando C. [1 ]
Suarez, Willian T. [2 ]
Alonso-Chamarro, Julian [3 ]
Fatibello-Filho, Orlando [1 ]
Faria, Ronaldo C. [1 ]
机构：
[1] Univ Fed Sao Carlos, Ctr Exact Sci & Technol, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Fed Vicosa, Exact & Technol Sci Ctr, Dept Chem, BR-36570000 Vicosa, MG, Brazil
[3] Autonomous Univ Barcelona, Dept Chem, Grp Sensors & Biosensors, Bellaterra 08193, Spain
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2014年 / 12卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
Ascorbic acid determination; Flow analysis; LTCC; LED photometer; Multicommutation; SOLID-PHASE REACTOR; INJECTION SPECTROPHOTOMETRIC DETERMINATION; OIL POLYURETHANE COMPOSITE; PHARMACEUTICAL FORMULATIONS; SYSTEM; COPPER; MULTICOMMUTATION; CAPTOPRIL; ELECTRODE; GRAPHITE;
D O I：
10.2478/s11532-013-0377-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An automated flow analyzer based on low temperature co-fired ceramic (LTCC), a solid-phase reactor (SPR) and a low-cost photometer was designed for ascorbic acid (AA) determination in pharmaceutical formulations. It consists of a peristaltic pump, three-way solenoid valves, SPR to chemically convert Cu(II) into Cu(I), and a LTCC device for mixing the liberated copper with bathocuproine and detection. The flow cell in the LTCC employed an ultrabright LED - photodiode photometer. The analyzer successfully determined AA in pharmaceutical formulations. The analytical curve from 8.5x10(-6) to 7.0x10(-4) M gave a detection limit of 7.0x10(-7) M and a RSD of 2.1% for a 2.0x10(-4) M AA solution (n = 10). A high sampling frequency of 102 h(-1) and low reagent and sample consumption (150 A mu L) resulted.
引用
收藏
页码：341 / 347
页数：7
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