A facile and efficient multicomponent ultrasound-assisted "on water" synthesis of benzodiazepine ring

被引：21

作者：

Maury, Suresh Kumar ^{[1
]}

Kumar, Dhirendra ^{[1
]}

Kamal, Arsala ^{[1
]}

Singh, Himanshu Kumar ^{[1
]}

Kumari, Savita ^{[1
]}

Singh, Sundaram ^{[1
]}

机构：

[1] Indian Inst Technol BHU, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

MOLECULAR DIVERSITY | 2021年 / 25卷 / 01期

关键词：

Ultrasound irradiation; Water synthesis; Isatin; 1,3-Dicarbonyl; 1,2-Phenylenediamine; ONE-POT SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; 1,5-BENZODIAZEPINE DERIVATIVES; SPIROOXINDOLE DERIVATIVES; ORGANIC-SYNTHESIS; L-PROLINE; CATALYST; SCAFFOLD; ACID; CYCLOADDITION;

D O I：

10.1007/s11030-019-10031-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A facile and efficient multicomponent synthesis of benzodiazepine ring in water under ultrasound rradiation is reported first time. The current procedure escapes traditional chromatography and purification process and provided the product in excellent yields of 95% as compared to conventional methods. The approach was also validated on gram-scale synthesis. [GRAPHICS] .

引用

页码：131 / 142

页数：12

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