Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience

被引：4

作者：

Boehm, Alexandra ^{[1
,2
]}

Sperr, Wolfgang R. ^{[3
]}

Kalhs, Peter ^{[1
]}

Greinix, Hildegard ^{[1
]}

Valent, Peter ^{[3
]}

Worel, Nina ^{[4
]}

Kainz, Alexander ^{[5
]}

Mitterbauer, Margit ^{[1
]}

Bojic, Marija ^{[1
]}

Rabitsch, Werner ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Bone Marrow Transplantat Unit, A-1090 Vienna, Austria

[2] Elisabethinen Hosp Linz, Dept Internal Med 1, Linz, Austria

[3] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria

[4] Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, A-1090 Vienna, Austria

[5] Med Univ Vienna, Dept Nephrol, A-1090 Vienna, Austria

来源：

WIENER KLINISCHE WOCHENSCHRIFT | 2014年 / 126卷 / 1-2期

关键词：

MDS; sAML; Allogeneic stem cell transplantation; Ferritin; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; VERSUS-HOST-DISEASE; PROGNOSTIC IMPACT; SCORING SYSTEM; COMORBIDITY; CHEMOTHERAPY; TRANSFUSION; COMBINATION; THERAPY;

D O I：

10.1007/s00508-013-0449-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed a single center analysis of 60 adult patients (33 males and 27 females) with myelodysplastic syndromes (MDS) or secondary acute myeloid leukemia (AML) who underwent allogeneic hematopoietic stem cell transplantation (HCT) at our institution. Allogeneic stem cell in patients were transplanted between 1988 and 2010, 28 had an human leukocyte antigen (HLA)-identical sibling donor, 23 had an HLA-identical unrelated donor, and 9 had an 1 allele mismatched donor. The median age at time of HCT was 44 (range: 18-68) years. Conditioning therapy was myeloablative in 36 patients and consisted of a reduced-intensity conditioning (RIC) regimen in 24 patients. Graft-versus-host disease (GvHD) prophylaxis was performed with a combination of methotrexate and cyclosporine A in 36 patients, and cyclosporine A plus mycophenolate mofetil in 24 patients. The 10-year probability of overall survival was 46 %. In a multivariate analysis, we identified pretransplantation serum ferritin as the only independent adverse prognostic variable predicting survival in our patients.

引用

页码：23 / 29

页数：7

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