The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses

被引：17

作者：

Davis, Kaori Uchiumi ^{[1
,2
]}

Sheats, M. Katie ^{[1
,2
]}

机构：

[1] North Carolina State Univ, Coll Vet Med, Dept Clin Sci, 1060 William Moore Dr, Raleigh, NC 27607 USA

[2] North Carolina State Univ, Ctr Comparat Med & Translat Res, 1060 William Moore Dr, Raleigh, NC 27607 USA

来源：

INFLAMMATION | 2021年 / 44卷 / 02期

基金：

美国国家卫生研究院;

关键词：

asthma; neutrophils; noneosinophilic asthma; equine asthma syndrome; nonallergic asthma; horses; OBSTRUCTIVE PULMONARY-DISEASE; RECURRENT AIRWAY-OBSTRUCTION; BRONCHOALVEOLAR LAVAGE FLUID; OXIDATIVE STRESS; EXTRACELLULAR TRAPS; ORGANIC DUST; EPITHELIAL-CELLS; ALLERGIC-ASTHMA; GENE-EXPRESSION; IL-8; PRODUCTION;

D O I：

10.1007/s10753-020-01362-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Asthma is a common and debilitating chronic airway disease that affects people and horses of all ages worldwide. While asthma in humans most commonly involves an excessive type 2 immune response and eosinophilic inflammation, neutrophils have also been recognized as key players in the pathophysiology of asthma, including in the severe asthma phenotype where neutrophilic inflammation predominates. Severe equine asthma syndrome (sEAS) features prominent neutrophilic inflammation and has been increasingly used as a naturally occurring animal model for the study of human neutrophilic asthma. This comparative review examines the recent literature in order to explore the role of neutrophil inflammatory functions in the pathophysiology and immunology of asthma in humans and horses.

引用

收藏

页码：450 / 465

页数：16

相关论文

共 173 条

[1] Expression of CD11b and CD18 on polymorphonuclear neutrophils stimulated with interleukin-2 [J].

Abdel-Salaivi, Bahaa K. A. ;

Ebaid, Hossam .

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 39 (02) :209-215

[2] A Neutrophil Timer Coordinates Immune Defense and Vascular Protection (vol 50, pg 390, 2019) [J].

Adrover, Jose M. ;

del Fresno, Carlos ;

Crainiciuc, Georgiana ;

Cuartero, Maria Isabel ;

Casanova-Acebes, Maria ;

Weiss, Linnea A. ;

Huerga-Encabo, Hector ;

Silvestre-Roig, Carlos ;

Rossaint, Jan ;

Cossio, Itziar ;

Lechuga-Vieco, Ana V. ;

Garcia-Prieto, Jaime ;

Gomez-Parrizas, Monica ;

Quintana, Juan A. ;

Ballesteros, Ivan ;

Martin-Salamanca, Sandra ;

Aroca-Crevillen, Alejandra ;

Chong, Shu Zhen ;

Evrard, Maximilien ;

Balabanian, Karl ;

Lopez, Jorge ;

Bidzhekov, Kiril ;

Bachelerie, Francoise ;

Abad-Santos, Francisco ;

Munoz-Calleja, Cecilia ;

Zarbock, Alexander ;

Soehnlein, Oliver ;

Weber, Christian ;

Lai Guan Ng ;

Lopez-Rodriguez, Cristina ;

Sancho, David ;

Moro, Maria A. ;

Ibanez, Borja ;

Hidalgo, Andres .

IMMUNITY, 2019, 51 (05) :966-967

[3] Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction [J].

Ainsworth, DM ;

Wagner, B ;

Franchini, M ;

Grünig, G ;

Erb, HN ;

Tan, JY .

AMERICAN JOURNAL OF VETERINARY RESEARCH, 2006, 67 (04) :669-677

[4] Recurrent airway obstruction (RAO) in horses is characterized by IFN-γ and IL-8 production in bronchoalveolar lavage cells [J].

Ainsworth, DM ;

Grünig, G ;

Matychak, MB ;

Young, J ;

Wagner, B ;

Erb, HN ;

Antczak, DF .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2003, 96 (1-2) :83-91

[5] Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma by upregulation of antioxidants and attenuation of Th17 immune responses in the airways [J].

Al-Harbi, Naif O. ;

Nadeem, Ahmed ;

Ahmad, Sheikh F. ;

AlThagfan, Sultan S. ;

Alqinyah, Mohammed ;

Alqahtani, Faleh ;

Ibrahim, Khalid E. ;

Al-Harbi, Mohammed M. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 855 :276-284

[6] High-dimensional analysis of the murine myeloid cell system [J].

Becher, Burkhard ;

Schlitzer, Andreas ;

Chen, Jinmiao ;

Mair, Florian ;

Sumatoh, Hermi R. ;

Teng, Karen Wei Weng ;

Low, Donovan ;

Ruedl, Christiane ;

Riccardi-Castagnoli, Paola ;

Poidinger, Michael ;

Greter, Melanie ;

Ginhoux, Florent ;

Newell, Evan W. .

NATURE IMMUNOLOGY, 2014, 15 (12) :1181-1189

[7] Endotoxin concentrations within the breathing zone of horses are higher in stables than on pasture [J].

Berndt, Annerose ;

Derksen, Frederik J. ;

Robinson, N. Edward .

VETERINARY JOURNAL, 2010, 183 (01) :54-57

[8] Biomarkers of oxidative stress and antioxidants in severe asthma A Prospective Case-Control Study [J].

Bishopp, Abigail ;

Sathyamurthy, Ramamurthy ;

Manney, Sarah ;

Webbster, Craig ;

Krishna, Mamidipudi Thirumala ;

Mansur, Adel H. .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2017, 118 (04) :445-451

[9] Equine asthma: Integrative biologic relevance of a recently proposed nomenclature [J].

Bond, Stephanie ;

Leguillette, Renaud ;

Richard, Eric A. ;

Couetil, Laurent ;

Lavoie, Jean-Pierre ;

Martin, James G. ;

Pirie, R. Scott .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 2018, 32 (06) :2088-2098

[10] In Vitro effects of tamoxifen on equine neutrophils [J].

Borlone, C. ;

Morales, N. ;

Henriquez, C. ;

Folch, H. ;

Olave, C. ;

Sarmiento, J. ;

Uberti, B. ;

Moran, G. .

RESEARCH IN VETERINARY SCIENCE, 2017, 110 :60-64

← 1 2 3 4 5 6 7 8 9 10 →