Modular and Divergent Syntheses of Protoberberine and Protonitidine Alkaloids

被引：13

作者：

Liu, Kai ^{[1
]}

Jiang, Xuefeng ^{[1
,2
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 04期

关键词：

O BOND FORMATION; MECHANISM DISTINCT; BERBERINE; ACCESS; ISOQUINOLINES; DERIVATIVES; ANNULATION; ARYLATION; STRATEGY; CASCADE;

D O I：

10.1021/acs.orglett.0c04310

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modularly convergent and divergent strategy was established for the family synthesis of both protoberberine and protonitidine alkaloids. The robust, scalable, and flexible synthetic route featured a collective preparation of protoberberine and protonitidine alkaloids from a common isoquinoline assembled from pyridyne as the key synthon, which was based on the selective N-C or C-C cyclization via distinct processes. Through the strategy, 20 protoberberine alkaloids, 5 protonitidine alkaloids, and 11 analogues with diverse substituents were comprehensively aquired.

引用

页码：1327 / 1332

页数：6

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