TREK-1 is a heat-activated background K+ channel

被引：395

作者：

Maingret, F ^{[1
]}

Lauritzen, I ^{[1
]}

Patel, AJ ^{[1
]}

Heurteaux, C ^{[1
]}

Reyes, R ^{[1
]}

Lesage, F ^{[1
]}

Lazdunski, M ^{[1
]}

Honoré, E ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UPR 411, F-06560 Valbonne, France

来源：

EMBO JOURNAL | 2000年 / 19卷 / 11期

关键词：

DRG neurons; hypothalamus; 2P domain K+ channels; thermoreceptors;

D O I：

10.1093/emboj/19.11.2483

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres as well as in the anterior/preoptic hypothalamus. The two-pore domain mechano-gated K+ channel TREK-1 is highly expressed within these areas. Moreover, TREK-1 is opened gradually and reversibly by heat. A 10 degrees C rise enhances TREK-1 current amplitude by similar to 7-fold. Prostaglandin E2 and cAMP, which are strong sensitizers of peripheral and central thermoreceptors, reverse the thermal opening of TREK-1 via protein kinase A-mediated phosphorylation of Ser333. Expression of TREK-1 in peripheral sensory neurons as well as in central hypothalamic neurons makes this K+ channel an ideal candidate as a physiological thermoreceptor.

引用

页码：2483 / 2491

页数：9

共 47 条

[31] Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons [J].

Nagy, I ;

Rang, H .

NEUROSCIENCE, 1999, 88 (04) :995-997

[32] OSMOSENSITIVITY OF PREOPTIC THERMOSENSITIVE NEURONS IN HYPOTHALAMIC SLICES INVITRO [J].

NAKASHIMA, T ;

HORI, T ;

KIYOHARA, T ;

SHIBATA, M .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1985, 405 (02) :112-117

[33] Inhalational anesthetics activate two-pore-domain background K+ channels [J].

Patel, AJ ;

Honoré, E ;

Lesage, F ;

Fink, M ;

Romey, G ;

Lazdunski, M .

NATURE NEUROSCIENCE, 1999, 2 (05) :422-426

[34] A mammalian two pore domain mechano-gated S-like K+ channel [J].

Patel, AJ ;

Honoré, E ;

Maingret, F ;

Lesage, F ;

Fink, M ;

Duprat, F ;

Lazdunski, M .

EMBO JOURNAL, 1998, 17 (15) :4283-4290

[35] EVIDENCE FOR INVOLVEMENT OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE IN FEVER GENESIS [J].

PHILIPPDORMSTON, WK .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1976, 362 (03) :223-227

[36] THE EFFECT OF HALOTHANE ON THERMOSENSITIVE NEURONS IN THE PREOPTIC REGION OF THE ANTERIOR HYPOTHALAMUS IN ACUTELY INSTRUMENTED CATS [J].

POTERACK, KA ;

KAMPINE, JP ;

SCHMELING, WT .

ANESTHESIOLOGY, 1991, 75 (04) :625-633

[37] Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel [J].

Reichling, DB ;

Levine, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) :7006-7011

[38]

Reyes R, 2000, NEUROSCIENCE, V95, P893

[39] Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney [J].

Reyes, R ;

Duprat, F ;

Lesage, F ;

Fink, M ;

Salinas, M ;

Farman, N ;

Lazdunski, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (47) :30863-30869

[40] Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure [J].

Salinas, M ;

Reyes, R ;

Lesage, F ;

Fosset, M ;

Heurteaux, C ;

Romey, G ;

Lazdunski, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) :11751-11760

← 1 2 3 4 5 →