TREK-1 is a heat-activated background K+ channel

被引：395

作者：

Maingret, F ^{[1
]}

Lauritzen, I ^{[1
]}

Patel, AJ ^{[1
]}

Heurteaux, C ^{[1
]}

Reyes, R ^{[1
]}

Lesage, F ^{[1
]}

Lazdunski, M ^{[1
]}

Honoré, E ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UPR 411, F-06560 Valbonne, France

来源：

EMBO JOURNAL | 2000年 / 19卷 / 11期

关键词：

DRG neurons; hypothalamus; 2P domain K+ channels; thermoreceptors;

D O I：

10.1093/emboj/19.11.2483

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres as well as in the anterior/preoptic hypothalamus. The two-pore domain mechano-gated K+ channel TREK-1 is highly expressed within these areas. Moreover, TREK-1 is opened gradually and reversibly by heat. A 10 degrees C rise enhances TREK-1 current amplitude by similar to 7-fold. Prostaglandin E2 and cAMP, which are strong sensitizers of peripheral and central thermoreceptors, reverse the thermal opening of TREK-1 via protein kinase A-mediated phosphorylation of Ser333. Expression of TREK-1 in peripheral sensory neurons as well as in central hypothalamic neurons makes this K+ channel an ideal candidate as a physiological thermoreceptor.

引用

页码：2483 / 2491

页数：9

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