Health-related quality of life in patients with pancreatic cancer

被引：42
作者：
Mueller-Nordhorn, J. [1 ]
Roll, S.
Boehmig, M.
Nocon, M.
Reich, A.
Braun, C.
Noesselt, L.
Wiedenmann, B.
Willich, S. N.
Brueggenjuergen, B.
机构：
[1] Charite Univ Med Berlin, Med Ctr, Inst Social Med Epidemiol & Hlth Econ, DE-10098 Berlin, Germany
[2] Charite Univ Med Berlin, Med Ctr, Dept Med, Div Gastroenterol & Hepatol, DE-10098 Berlin, Germany
来源：
DIGESTION | 2006年 / 74卷 / 02期
关键词：
pancreatic cancer; health related quality of life; EORTC; EQ-5D;
D O I：
10.1159/000098177
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background: Pancreatic cancer is an aggressive cancer with low survival time, with health-related quality of life (HRQoL) being of major importance. The aim of our study was to assess both generic and disease-specific HRQoL in patients with pancreatic cancer. Methods: Patients with pancreatic cancer were consecutively included at admission to hospital. HRQoL was determined with the disease-specific European Organization for Research and Treatment of Cancer (EORTC) and generic EuroQoL (EQ-5D) health status instruments. Scores of patients were compared to those of norm populations. The association of symptoms with overall HRQoL was analysed using linear regression. Results: A total of 45 patients with pancreatic cancer were included. The mean age was 64 years, 53% were females. Of all patients, 44% had metastases at the time of admission. HRQoL was significantly impaired for most EORTC and EQ-5D scales in comparison to norm populations. Symptoms of fatigue (-0.34 regression coefficient; 95% CI -0.63, -0.11) and pain (-0.21; 95% CI -0.39, -0.02) were significantly associated with impaired overall HRQoL. Conclusions: HRQoL was severely impaired in patients with pancreatic cancer. Symptom control and palliative care appear to be of particular importance. Copyright (c) 2006 S. Karger AG, Basel.
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页码：118 / 125
页数：8
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