To investigate the expression of osteopontin (OPN) and its receptor integrin alpha nu I(2)3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and alpha nu I(2)3 in the placenta of the pregnant women with preeclampsia and healthy pregnant women was detected by immunohistochemistry, Western blotting and RT-PCR. Our results showed that OPN and alpha nu I(2)3 protein were expressed in the placenta from normal pregnant woman and those with preeclampsia. OPN was located in the placental syncytiotrophoblasts and the cytoplasm of capillary endothelial cells and integrin alpha nu I(2)3 was mainly expressed on the surface of trophoblast cells. Expression of OPN and integrin alpha nu I(2)3 in the placental tissue from preeclampsia subjects was significantly lower than that from the control group (P < 0.05). Compared with the control group, expression of OPN in the placental tissue from preeclampsia group was significantly lower (P < 0.05) but there was no significant difference in the expression of alpha nu and beta 3 between the preeclampsia group and the controls. It is concluded that OPN and its receptor integrin alpha nu I(2)3 may be involved in the pathogenesis of preeclampsia.
机构:
Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, IranKermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Zakeri, Saba
Rahimi, Zohreh
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Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Kermanshah Univ Med Sci, Med Biol Res Ctr, Med Sch, Kermanshah, Iran
Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, IranKermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Rahimi, Zohreh
Jalilian, Nazanin
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Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, IranKermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Jalilian, Nazanin
Vaisi-Raygani, Asad
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Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, IranKermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Vaisi-Raygani, Asad
Rezvani, Ali
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Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, IranKermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Rezvani, Ali
Dastafkan, Zahra
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Kermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Kermanshah Univ Med Sci, Med Genet Lab, Kermanshah, IranKermanshah Univ Med Sci, Med Sch, Dept Clin Biochem, Kermanshah, Iran
Dastafkan, Zahra
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY,
2023,
12
(01):
: 112
-
119
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Erez, Offer
Romero, Roberto
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h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Romero, Roberto
Kim, Sung-Su
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h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Kim, Sung-Su
Kim, Jung-Sun
论文数: 0引用数: 0
h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Kim, Jung-Sun
Kim, Yeon Mee
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h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Kim, Yeon Mee
Wildman, Derek E.
论文数: 0引用数: 0
h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wildman, Derek E.
Than, Nandor Gabor
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h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Than, Nandor Gabor
Mazaki-Tovi, Shali
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h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Mazaki-Tovi, Shali
Gotsch, Francesca
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机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Gotsch, Francesca
Pineles, Beth
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h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Pineles, Beth
Kusanovic, Juan Pedro
论文数: 0引用数: 0
h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Kusanovic, Juan Pedro
Espinoza, Jimmy
论文数: 0引用数: 0
h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Espinoza, Jimmy
Mittal, Pooja
论文数: 0引用数: 0
h-index: 0
机构:
NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Mittal, Pooja
Mazor, Moshe
论文数: 0引用数: 0
h-index: 0
机构:
Ben Gurion Univ Negev, Fac Hlth Sci, Dept Obstet & Gynecol, Soroka Univ Med Ctr, IL-84105 Beer Sheva, IsraelNICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Mazor, Moshe
Hassan, Sonia S.
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NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA
Hassan, Sonia S.
Kim, Chong Jai
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NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USANICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA