COVID-19 vaccines: modes of immune activation and future challenges

被引：538

作者：

Teijaro, John R. ^{[1
]}

Farber, Donna L. ^{[2
,3
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[2] Columbia Univ Irving Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA

[3] Columbia Univ Irving Med Ctr, Dept Surg, New York, NY 10032 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2021年 / 21卷 / 04期

关键词：

D O I：

10.1038/s41577-021-00526-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This Comment outlines how the recently licensed vaccines for COVID-19 activate innate immune mechanisms to promote immune memory to SARS-CoV-2. The authors also consider future challenges that could limit vaccine efficacy. The new vaccines against SARS-CoV-2 are novel in terms of specificity, their wide dissemination across the global population and the inclusion of newly licensed mRNA platforms. We discuss here how the approved vaccines trigger innate immunity to promote durable immunological memory and consider the future implications of protecting populations with these vaccines.

引用

页码：195 / 197

页数：3

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