Novel targets for the treatment of autosomal dominant polycystic kidney disease

被引：31

作者：

Belibi, Franck A. ^{[1
]}

Edelstein, Charles L. ^{[1
]}

机构：

[1] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO 80045 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2010年 / 19卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CONVERTING-ENZYME INHIBITORS; TUMOR-NECROSIS-FACTOR; RENAL CYSTIC-DISEASE; GROWTH-FACTOR; EPITHELIAL-CELLS; IN-VITRO; RAPAMYCIN TOR; RODENT MODEL; PROGRESSION; KINASE;

D O I：

10.1517/13543781003588491

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered in the review: The purpose of this review is to summarize the molecular and cellular targets involved in cystogenesis and to update on the promising therapies that are being developed and tested based on knowledge of these molecular and cellular targets. What the reader will gain: Insight into the pathogenesis of PKD and how a better understanding of the pathogenesis of PKD has led to the development of potential therapies to inhibit cyst formation and/or growth and improve kidney function. Take home message: The results of animal studies in PKD have led to the development of clinical trials testing potential new therapies to reduce cyst formation and/or growth. A vasopressin V2 receptor antagonist, mTOR inhibitors, blockade of the renin-angiotensin system and statins that reduce cyst formation and improve renal function in animal models of PKD are being tested in interventional studies in humans.

引用

页码：315 / 328

页数：14

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