Study on the digestion of milk with prebiotic carbohydrates in a simulated gastrointestinal model

被引:22
作者
Ferreira-Lazarte, Alvaro [1 ]
Montilla, Antonia [1 ]
Mulet-Cabero, Ana-Isabel [2 ]
Rigby, Neil [2 ,3 ]
Olano, Agustin [1 ]
Mackie, Alan [2 ,3 ]
Villamiel, Mar [1 ]
机构
[1] CIAL CSIC UAM, Inst Invest Ciencias Alimentac, C Nicolas Cabrera,9,Campus Univ Autonoma Madrid, Madrid 28049, Spain
[2] Inst Food Res, Norwich Res Pk, Norwich NR4 7UA, Norfolk, England
[3] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England
关键词
Lactulose oligosaccharides; Prebiotics; Digestion; Milk; Galacto-oligosaccharides; GALACTO-OLIGOSACCHARIDES; LACTULOSE; FOOD; MICROBIOTA; RATS;
D O I
10.1016/j.jff.2017.03.031
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The behaviour of oligosaccharides from lactulose (OsLu) included with milk was examined during in vitro gastrointestinal digestion using the Infogest protocol as well as some small intestine rat extract. The digestion was compared with commercial prebiotics GOS and Duphalac (R). Electrophoretic analysis demonstrated that the prebiotic carbohydrates did not modify the gastric digestion of dairy proteins. Similarly, no significant effect of gastrointestinal digestion was shown on the prebiotic studied. In contrast, under the intestinal conditions using a rat extract, the oligosaccharides present in OsLu samples were less digested (<15%) than in GOS (35%). Moreover, lactulose was more prone to digestion than their corresponding trisaccharides. These results demonstrate the limited digestion of OsLu and their availability to reach the large intestine as prebiotic. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:149 / 154
页数:6
相关论文
共 22 条
[1]   Acute and Repeated Dose (28 Days) Oral Safety Studies of ALIBIRD in Rats [J].
Anadon, Arturo ;
Martinez, Maria A. ;
Ares, Irma ;
Castellano, Victor ;
Martinez-Larranaga, Maria R. ;
Corzo, Nieves ;
Olano, Agustin ;
Montilla, Antonia ;
Recio, Isidra ;
Martinez-Maqueda, Daniel ;
Miralles, Beatriz ;
Fornari, Tiziana ;
Garcia-Risco, Monica R. ;
Gonzalez, Monserrat ;
Reglero, Guillermo .
JOURNAL OF FOOD PROTECTION, 2013, 76 (07) :1226-1239
[2]   Synthesis of Oligosaccharides Derived from Lactulose (OsLu) Using Soluble and Immobilized Aspergillus oryzae β-Galactosidase [J].
Cardelle-Cobas, Alejandra ;
Olano, Agustin ;
Irazoqui, Gabriela ;
Giacomini, Cecilia ;
Batista-Viera, Francisco ;
Corzo, Nieves ;
Corzo-Martinez, Marta .
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2016, 4
[3]  
Corzo-Martinez M., 2013, IMPACT POWER ULTRASO
[4]   Dietary modulation of the human colonic microbiota: updating the concept of prebiotics [J].
Gibson, GR ;
Probert, HM ;
Van Loo, J ;
Rastall, RA ;
Roberfroid, MB .
NUTRITION RESEARCH REVIEWS, 2004, 17 (02) :259-275
[5]   Monomer and Linkage Type of Galacto-Oligosaccharides Affect Their Resistance to Ileal Digestion and Prebiotic Properties in Rats [J].
Hernandez-Hernandez, Oswaldo ;
Carmen Marin-Manzano, M. ;
Rubio, Luis A. ;
Javier Moreno, E. ;
Luz Sanz, M. ;
Clemente, Alfonso .
JOURNAL OF NUTRITION, 2012, 142 (07) :1232-1239
[6]   Analysis, structural characterization, and bioactivity of oligosaccharides derived from lactose [J].
Javier Moreno, F. ;
Montilla, Antonia ;
Villamiel, Mar ;
Corzo, Nieves ;
Olano, Agustin .
ELECTROPHORESIS, 2014, 35 (11) :1519-1534
[7]   Stability of oligosaccharides derived from lactulose during the processing of milk and apple juice [J].
Lopez-Sanz, Sara ;
Montilla, Antonia ;
Javier Moreno, F. ;
Villamiel, Mar .
FOOD CHEMISTRY, 2015, 183 :64-71
[8]   DIFFERENT GASTRIC, PANCREATIC, AND BILIARY RESPONSES TO SOLID-LIQUID OR HOMOGENIZED MEALS [J].
MALAGELADA, JR ;
GO, VLW ;
SUMMERSKILL, WHJ .
DIGESTIVE DISEASES AND SCIENCES, 1979, 24 (02) :101-110
[9]   In vitro digestibility of β-casein and β-lactoglobulin under simulated human gastric and duodenal conditions: A multi-laboratory evaluation [J].
Mandalari, G. ;
Adel-Patient, K. ;
Barkholt, V. ;
Baro, C. ;
Bennett, L. ;
Bublin, M. ;
Gaier, S. ;
Graser, G. ;
Ladics, G. S. ;
Mierzejewska, D. ;
Vassilopoulou, E. ;
Vissers, Y. M. ;
Zuidmeer, L. ;
Rigby, N. M. ;
Salt, L. J. ;
Defernez, M. ;
Mulholland, F. ;
Mackie, A. R. ;
Wickham, M. S. J. ;
Mills, E. N. C. .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2009, 55 (03) :372-381
[10]   A standardised static in vitro digestion method suitable for food - an international consensus [J].
Minekus, M. ;
Alminger, M. ;
Alvito, P. ;
Ballance, S. ;
Bohn, T. ;
Bourlieu, C. ;
Carriere, F. ;
Boutrou, R. ;
Corredig, M. ;
Dupont, D. ;
Dufour, C. ;
Egger, L. ;
Golding, M. ;
Karakaya, S. ;
Kirkhus, B. ;
Le Feunteun, S. ;
Lesmes, U. ;
Macierzanka, A. ;
Mackie, A. ;
Marze, S. ;
McClements, D. J. ;
Menard, O. ;
Recio, I. ;
Santos, C. N. ;
Singh, R. P. ;
Vegarud, G. E. ;
Wickham, M. S. J. ;
Weitschies, W. ;
Brodkorb, A. .
FOOD & FUNCTION, 2014, 5 (06) :1113-1124