Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives

被引：197
作者：
Ajani, Olayinka O. [1 ]
Obafemi, Craig A. [2 ]
Nwinyi, Obinna C. [3 ]
Akinpelu, David A. [4 ]
机构：
[1] Covenant Univ, Dept Chem, Ota, Ogun State, Nigeria
[2] Obafemi Awolowo Univ, Dept Chem, Ife, Osun State, Nigeria
[3] Covenant Univ, Dept Biol Sci, Ota, Ogun State, Nigeria
[4] Obafemi Awolowo Univ, Dept Microbiol, Ife, Osun State, Nigeria
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 01期
关键词：
3-Hydrazinoquinoxalin-2(1H)-one; Antibacterial activity; Gram positive bacteria; Microwave irradiation; STAPHYLOCOCCUS-AUREUS; BIOLOGICAL-ACTIVITIES; IN-VITRO; HYDRAZONES; RESISTANT; SPP; HYDRAZIDE; AGENTS;
D O I：
10.1016/j.bmc.2009.10.064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 3-{2-[1-(6-chloro-2-oxo-2H-chromen-3-yl)ethylidene]hydrazinyl}quinoxalin-2(1H)-one, 7 while 3-[2-(propan-2-ylidene) hydrazinyl]quinoxalin-2(1H)-one, 2 appeared to be the most active antifungal agent. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：214 / 221
页数：8
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