Ubiquitin hubs in oncogenic networks

被引：13

作者：

Crosetto, Nicola ^{[1
]}

Bienko, Marzena ^{[1
]}

Dikic, Ivan ^{[1
]}

机构：

[1] Goethe Univ Hosp, Inst Biochem 2, D-60599 Frankfurt, Germany

来源：

MOLECULAR CANCER RESEARCH | 2006年 / 4卷 / 12期

关键词：

D O I：

10.1158/1541-7786.MCR-06-0328

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ubiquitin is an important regulator of diverse biological functions including cell cycle progression, apoptosis, cell proliferation, and DNA damage responses. Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve anticancer therapy.

引用

页码：899 / 904

页数：6

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