Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?

被引：38

作者：

Maagaard, Anne ^{[1
,2
,3
]}

Kvale, Dag ^{[1
,3
]}

机构：

[1] Oslo Univ Hosp, Ulleval Dept Infect Dis, N-0407 Oslo, Norway

[2] Oslo Univ Hosp, Ulleval Dept Microbiol, N-0407 Oslo, Norway

[3] Univ Oslo, Fac Med, Oslo, Norway

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2009年 / 64卷 / 05期

关键词：

HIV-1; mitochondria; DNA polymerase gamma; nucleoside reverse transcriptase inhibitors; persistent immune activation; REVERSE-TRANSCRIPTASE INHIBITORS; BLOOD MONONUCLEAR-CELLS; SUBCUTANEOUS ADIPOSE-TISSUE; DNA-POLYMERASE-GAMMA; ANTIVIRAL NUCLEOSIDE ANALOGS; LACTIC-ACIDOSIS; RISK-FACTORS; PERIPHERAL LIPOATROPHY; IMMUNE ACTIVATION; T-CELLS;

D O I：

10.1093/jac/dkp316

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mitochondrial toxicity contributes to serious adverse effects observed in HIV-infected individuals treated with nucleoside reverse transcriptase inhibitors (NRTIs). However, similar mitochondrial abnormalities have recently been found even in treatment-naive patients, suggesting that chronic HIV per se could contribute to the toxicity observed in NRTI-exposed individuals. This review gives a current status of the field, with particular focus on recent observations suggesting that distinct mechanisms might cause such toxicity in both NRTI-exposed individuals and those naive to antiretroviral treatment.

引用

页码：901 / 909

页数：9

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