Synthesis of New Fluorine-Containing 1,2,3,4-Tetrahydroacridines

被引：9
作者：
Bonacorso, Helio Gauze [1 ]
de Moraes, Tatiana Soldati [1 ]
Zanatta, Nilo [1 ]
Pinto Martins, Marcos Antonio [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Chem, Res Grp Heterocycl Chem NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 20期
关键词：
Acridines; cyclohexene; PPA; tetrahydroacridines; ONE-STEP SYNTHESIS; QUINOLINES; DERIVATIVES; CYCLIZATION; ANALOGS; ETHERS;
D O I：
10.1080/00397910902803692
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for the synthesis of a novel series of four 5-trilfluoromethyl-1,2,3,4-tetrahydroacridines, by intramolecular cyclization reactions of 2-trifluoroacetyl-1-(arylamino)-cyclohexene using polyphosphoric acid (PPA), is described. The six new enaminoketone intermediates were obtained by an oxygen-nitrogen exchange reaction from 2-trifluoroacetyl-1-methoxycyclohexene with six 4-substituted anilines.
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页码：3677 / 3686
页数：10
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