Water driven transformation of a nonionic microemulsion into liquid crystalline phase: Structural characterizations and drug release behavior

被引:7
作者
Gandhi, Sonam M. [1 ]
Khan, Aslam K. [1 ]
Rathod, Sachin [1 ,2 ]
Jain, Rupesh [3 ]
Dubey, Sunil K. [3 ]
Ray, Debes [4 ]
Aswal, Vinod K. [4 ]
Joshi, Amita [2 ]
Bahadur, Pratap [5 ]
Tiwari, Sanjay [1 ]
机构
[1] Uka Tarsadia Univ, Maliba Pharm Coll, Gopal Vidyanagar Campus, Surat 394350, India
[2] BV Patel PERO Ctr, Ahmadabad 380054, Gujarat, India
[3] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India
[4] Bhabha Atom Res Ctr, Solid State Phys Div, Mumbai 400085, Maharashtra, India
[5] Veer Narmad South Gujarat Univ, Dept Chem, Surat 395007, India
关键词
Microemulsion; In situ transformation; Paclitaxel; Liquid crystalline; Controlled release; TPGS;
D O I
10.1016/j.molliq.2020.115239
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
This study reports structural characterization of liquid crystalline (LC) phase, formed through water driven transition in a nonionic microemulsion (ME). ME was formulated with alpha-tocopheryl polyethylene glycol succinate (TPGS) - Span 80 (3:1) as surfactant mixture and Captex 355 (a medium chain triglyceride) as oil phase. The role of surfactant mixture was elucidated by small angle neutron scattering (SANS) experiments. SANS analyses revealed that, at a specific ratio, TPGSmicelles and Span 80 vesicles interacted to form ellipsoidal nanostructures. The ME transformed to LC phase during progressive water addition. Subsequent structural changes were investigated by polarized lightmicroscopy, differential scanning calorimetry, texture profile and rheological analyses. Transition occurred with 19-24% water addition and it was accompanied with; (a) change of isotropic ME to birefringent LC phase, and (b) improvement in the rheological properties. Interestingly, the transition downshifted to 9.8% water level upon loading the oil phase with 20 mg/ml paclitaxel (PLX). LC structures remained stable at physiological temperature up to 72 h and offered controlled release of PLX under artificial sink conditions. We suggest that in situ development of LC phase can be explored to create long-residing intra-muscular depot formulations. (C) 2020 Elsevier B.V. All rights reserved.
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页数:8
相关论文
共 41 条
[1]   Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models [J].
Agarwal, Rachit ;
Jurney, Patrick ;
Raythatha, Mansi ;
Singh, Vikramjit ;
Sreenivasan, Sidlgata. V. ;
Shi, Li ;
Roy, Krishnendu .
ADVANCED HEALTHCARE MATERIALS, 2015, 4 (15) :2269-2280
[2]   Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment [J].
Bastiancich, Chiara ;
Bozzato, Elia ;
Luyten, Urszula ;
Danhier, Fabienne ;
Bastiat, Guillaume ;
Preat, Veronique .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 559 :220-227
[3]   PHASE-BEHAVIOR AND LYOTROPIC LIQUID-CRYSTALS IN CATIONIC SURFACTANT WATER-SYSTEMS [J].
BLACKMORE, ES ;
TIDDY, GJT .
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS II, 1988, 84 :1115-1127
[4]   Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied [J].
Brito, Daniela A. ;
Yang, Zhenye ;
Rieder, Conly L. .
JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :623-629
[5]   Rheological study on mucoadhesivity of some nasal powder formulations [J].
Callens, C ;
Ceulemans, J ;
Ludwig, A ;
Foreman, P ;
Remon, JP .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2003, 55 (03) :323-328
[6]   Rheological Characterization of Hydrogels from Alginate-Based Nanodispersion [J].
Cuomo, Francesca ;
Cofelice, Martina ;
Lopez, Francesco .
POLYMERS, 2019, 11 (02)
[7]  
Das A, 2019, COLLOID SURF A, V582
[8]   The influence of lung surfactant liquid crystalline nanostructures on respiratory drug delivery [J].
Das, Shyamal C. ;
Stewart, Peter J. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 514 (02) :465-474
[9]   Characterization of ibuprofen as a nontraditional plasticizer of ethyl cellulose [J].
De Brabander, C ;
Van den Mooter, G ;
Vervaet, C ;
Remon, JP .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (07) :1678-1685
[10]   Basic principles of drug delivery systems - the case of paclitaxel [J].
Ezrahi, S. ;
Aserin, A. ;
Garti, N. .
ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2019, 263 :95-130