Role of Flagella in the Pathogenesis of Helicobacter pylori

被引：160

作者：

Gu, Haiying ^{[1
]}

机构：

[1] Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China

来源：

CURRENT MICROBIOLOGY | 2017年 / 74卷 / 07期

关键词：

SP NOV; DUODENAL COLONIZATION; GNOTOBIOTIC PIGLETS; INTESTINAL-MUCOSA; IMMUNE-RESPONSE; CHEMOTAXIS; MOTILITY; PROTEIN; GENE; ACTIVATION;

D O I：

10.1007/s00284-017-1256-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This review aimed to investigate the role of Helicobacter pylori flagella on the pathogenicity of this bacterium in humans. Helicobacter pylori is a flagellated pathogen that colonizes the human gastroduodenal mucosa and produces inflammation, and is responsible for gastrointestinal disease. Its pathogenesis is attributed to colonization and virulence factors. The primary function of H. pylori flagella is to provide motility. We believe that H. pylori flagella play an important role in the colonization of the gastrointestinal mucosa. Therefore, we reviewed previous studies on flagellar morphology and motility in order to explore the relationship between H. pylori flagella and pathogenicity. Further investigation is required to confirm the association between flagella and pathogenicity in H. pylori.

引用

页码：863 / 869

页数：7

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