Dynamics of GABA(A) receptor binding in the ventromedial hypothalamus during postnatal development in the rat

被引:5
作者
Clark, AS
Robinson, S
Henderson, LP
机构
[1] DARTMOUTH COLL SCH MED,DEPT PHYSIOL,HANOVER,NH 03755
[2] DARTMOUTH COLL SCH MED,DEPT BIOCHEM,HANOVER,NH 03755
来源
DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 103卷 / 02期
关键词
GABA(A) receptor; ventromedial hypothalamus; hippocampus; muscimol binding; sexual differentiation; gonadal hormone;
D O I
10.1016/S0165-3806(97)81795-6
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In vitro quantitative autoradiography of [H-3]muscimol binding was used to examine the developmental pattern of GABA(A) receptor expression in the ventromedial hypothalamus (VMN) of Long-Evans rats. Peak levels of [H-3]muscimol binding were observed in the VMN on postnatal day 14 (PN14), binding levels were significantly lower in the VMN at earlier (PN0 and PN7) and later (PN70) ages. The developmental pattern of [H-3]muscimol binding observed in the VMN differed from that seen in the hippocampus where binding was found to increase progressively from PN0 to PN14 and was maintained at high levels in adulthood. Although the profile of GABA(A) receptor expression in the developing VMN undergoes considerable modification during the critical period for sexual differentiation, no significant differences in [H-3]muscimol binding were observed between male and female animals at any developmental age. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:195 / 198
页数:4
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