Alpha particle spectroscopy using FNTD and SIM super-resolution microscopy

被引:9
作者
Kouwenberg, J. J. M. [1 ]
Kremers, G. J. [2 ]
Slotman, J. A. [2 ]
Wolterbeek, H. T. [1 ]
Houtsmuller, A. B. [2 ]
Denkova, A. G. [1 ]
Bos, A. J. J. [1 ]
机构
[1] Delft Univ Technol, Fac Tech Nat Wetenschappen, Radiat Sci & Technol, Mekelweg 15, Delft, Netherlands
[2] Erasmus MC, Erasmus Opt Imaging Ctr, S Gravendijkwal 230, Rotterdam, Netherlands
关键词
Alpha radiation; FNTD; SIM; HEAVY CHARGED-PARTICLES; NUCLEAR TRACK DETECTORS; FLUORESCENCE MICROSCOPY; STRUCTURED ILLUMINATION; THERAPY; EMITTERS; DOSIMETRY; CANCER; CELLS; LIPOSOMES;
D O I
10.1111/jmi.12686
中图分类号
TH742 [显微镜];
学科分类号
摘要
Structured illumination microscopy (SIM) for the imaging of alpha particle tracks in fluorescent nuclear track detectors (FNTD) was evaluated and compared to confocal laser scanning microscopy (CLSM). FNTDs were irradiated with an external alpha source and imaged using both methodologies. SIM imaging resulted in improved resolution, without increase in scan time. Alpha particle energy estimation based on the track length, direction and intensity produced results in good agreement with the expected alpha particle energy distribution. A pronounced difference was seen in the spatial scattering of alpha particles in the detectors, where SIM showed an almost 50% reduction compared to CLSM. The improved resolution of SIM allows for more detailed studies of the tracks induced by ionising particles. The combination of SIM and FNTDs for alpha radiation paves the way for affordable and fast alpha spectroscopy and dosimetry.
引用
收藏
页码:326 / 334
页数:9
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