Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

被引：31

作者：

Barker, Samuel ^{[1
]}

Rhoads, Eric ^{[1
]}

Lindquist, Paul ^{[2
]}

Vreugdenhil, Martin ^{[3
]}

Mullner, Peter ^{[2
]}

机构：

[1] Boise State Univ, Dept Mech & Biomed Engn, Dept Mat Sci & Engn, 1910 Univ Dr,Mail Stop 2090, Boise, ID 83725 USA

[2] Boise State Univ, Dept Mat Sci & Engn, 1910 Univ Dr,Mail Stop 2090, Boise, ID 83725 USA

[3] Univ Birmingham, Sch Clin & Expt Med, Vincent Dr, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME | 2016年 / 10卷 / 04期

关键词：

NI-MN-GA; ACTUATION; FIELD;

D O I：

10.1115/1.4034576

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Point-of-care diagnostic devices, micrototal analysis (mu TAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 mu l/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.

引用

页数：6

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