Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase

被引：22
作者：
Azevedo, Rafael D. S. [1 ]
Falcao, Kivia V. G. [1 ]
Assis, Caio R. D. [1 ,3 ]
Martins, Regildo M. G. [2 ]
Araujo, Marlyete C. [1 ]
Yogui, Gilvan T. [3 ]
Neves, Jorge L. [4 ]
Seabra, Gustavo M. [5 ,6 ]
Maia, Maria B. S. [7 ]
Amaral, Ian P. G. [8 ]
Leite, Ana C. R. [9 ]
Bezerra, Ranilson S. [1 ]
机构：
[1] Univ Fed Pernambuco, Dept Bioquim, Lab Enzimol LABENZ, Recife, PE, Brazil
[2] Univ Fed Amazonas UFAM, Manaus, Amazonas, Brazil
[3] Univ Fed Pernambuco, Dept Oceanog, Lab Compostos Organ Ecossistemas Costeiros & Mari, Recife, PE, Brazil
[4] Univ Fed Pernambuco, Dept Quim Fundamental, Lab Quim Biol LQB, Recife, PE, Brazil
[5] Univ Florida, Dept Med Chem, Sch Pharm, Gainesville, FL USA
[6] Univ Florida, Ctr Nat Prod Drug Discovery & Dev CNPD3, Sch Pharm, Gainesville, FL USA
[7] Univ Fed Pernambuco, Dept Fisiol & Farmacol, Lab Farmacol Prod Bioativos, Recife, PE, Brazil
[8] Univ Fed Paraiba UFPB, Ctr Biotecnol, Campus 1,Cidade Univ, Joao Pessoa, Paraiba, Brazil
[9] Univ Fed Alagoas UFAL, Dept Quim & Biotecnol, Lab Bioenerget Prof Anibal Vercesi, Maceio, Alagoas, Brazil
来源：
CHEMOSPHERE | 2021年 / 263卷
关键词：
Ca2+ transport; Molecular docking; Neurotoxicity; Nitric oxide; Pesticides; Reactive oxygen species;
D O I：
10.1016/j.chemosphere.2020.128029
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Pyriproxyfen is an insecticide used worldwide that acts as a biomimetic of juvenile hormone. This study investigated metabolic and synaptic impairments triggered by pyriproxyfen using zebrafish acetylcholinesterase (zbAChE) and mitochondria as markers. A brain zbAChE assay was performed in vitro and in vivo covering a range of pyriproxyfen concentrations (0.001-10 mu mol/L) to assess inhibition kinetics.
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页数：12
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