Evaluation of superparamagnetic iron oxide-polymer composite microcapsules for magnetic resonance-guided high-intensity focused ultrasound cancer surgery

被引：21

作者：

Sun, Yang ^{[1
]}

Zheng, Yuanyi ^{[1
]}

Li, Pan ^{[1
]}

Wang, Dong ^{[1
]}

Niu, Chengcheng ^{[1
]}

Gong, Yuping ^{[1
]}

Huang, Rongzhong ^{[1
]}

Wang, Zhibiao ^{[2
]}

Wang, Zhigang ^{[1
]}

Ran, Haitao ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing, Peoples R China

[2] Chongqing Med Univ, Coll Biomed Engn, Chongqing, Peoples R China

来源：

BMC CANCER | 2014年 / 14卷

关键词：

Cancer surgery; Hyperthermia; HIFU; MRI guidance; Iron oxide; Polymer; ABLATION; THERAPY; NANOPARTICLES; KIDNEY; TUMORS; LIVER;

D O I：

10.1186/1471-2407-14-800

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLGA-coated Fe3O4 microcapsules were combined with a magnetic resonance imaging-guided high-intensity focused ultrasound (MR-guided HIFU) platform, with the objective of investigating the effects of these composite microcapsules regarding MR-guided HIFU liver cancer surgery in vivo. Methods: PLGA-coated Fe3O4 microcapsules consisting of a liquid core and a PLGA-Fe3O4 shell were fabricated using a modified double emulsion evaporation method. Their acute biosafety was confirmed in vitro using MDA cells and in vivo using rabbits. To perform MR-guided HIFU surgery, the microcapsules were intravenously injected into a rabbit liver tumor model before MR-guided HIFU. T-2-weighted images and MR signal intensity in normal liver parenchyma and tumor tissue were acquired before and after injection, to assess the MR imaging ability of the microcapsules. After MR-guided HIFU ablation tissue temperature mapping, the coagulative volume and histopathology of the tumor tissue were analyzed to investigate the ablation effects of MR-guided HIFUs. Results: Scanning and transmission electron microscopy showed that the microcapsules displayed a spherical morphology and a shell-core structure (mean diameter, 587 nm). The hysteresis curve displayed the typical superparamagnetic properties of the microcapsules, which are critical to their application in MR-guided HIFU surgery. In MR-guided HIFU surgery, these microcapsules functioned as an MRI contrast agent, induced significant hyperthermal enhancement (P < 0.05) and significantly enhanced the volume of coagulative necrosis (P < 0.05). Conclusions: The administration of PLGA-coated Fe3O4 microcapsules is a potentially synergistic technique regarding the enhancement of MR-guided HIFU cancer surgery.

引用

页数：11

共 36 条

[21] Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound [J].

Jolesz, FA ;

Hynynen, K ;

McDannold, N ;

Freundlich, D ;

Kopelman, D .

GASTROENTEROLOGY, 2004, 127 (05) :S242-S247

[22] High-intensity focused ultrasound in the treatment of solid tumours [J].

Kennedy, JE .

NATURE REVIEWS CANCER, 2005, 5 (04) :321-327

[23]

Laurent S, 2010, FUTURE MED CHEM, V2, P427, DOI [10.4155/fmc.09.164, 10.4155/FMC.09.164]

[24] Synthesis of complexable fluorescent superparamagnetic iron oxide nanoparticles (FL SPIONs) and cell labeling for clinical application [J].

Lee, Jae-Ho ;

Schneider, Benjamin ;

Jordan, Elaine K. ;

Liu, Wei ;

Frank, Joseph A. .

ADVANCED MATERIALS, 2008, 20 (13) :2512-+

[25] Ablation of High-Intensity Focused Ultrasound Assisted with SonoVue on Rabbit VX2 Liver Tumors: Sequential Findings with Histopathology, Immunohistochemistry, and Enzyme Histochemistry [J].

Luo, Wen ;

Zhou, Xiaodong ;

Yu, Ming ;

He, Guangbin ;

Zheng, Xiaoying ;

Li, Qiuyang ;

Liu, Qing ;

Han, Zenghui ;

Zhang, Jun ;

Qian, Yunqiu .

ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (08) :2359-2368

[26]

Lynn John G., 1942, SCIENCE, V96, P119, DOI 10.1126/science.96.2483.119

[27] Engineered nanoparticles for biomolecular imaging [J].

Mahmoudi, Morteza ;

Serpooshan, Vahid ;

Laurent, Sophie .

NANOSCALE, 2011, 3 (08) :3007-3026

[28] Focal therapy with high-intensity-focused ultrasound in the treatment of localized prostate cancer [J].

Muto, Satoru ;

Yoshii, Takashi ;

Saito, Keisuke ;

Kamiyama, Yutaka ;

Ide, Hisamitsu ;

Horie, Shigeo .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 38 (03) :192-199

[29] Real-time volumetric MRI thermometry of focused ultrasound ablation in vivo: a feasibility study in pig liver and kidney [J].

Quesson, Bruno ;

Laurent, Christophe ;

Maclair, Gregory ;

de Senneville, Baudouin Denis ;

Mougenot, Charles ;

Ries, Mario ;

Carteret, Thibault ;

Rullier, Anne ;

Moonen, Chrit T. W. .

NMR IN BIOMEDICINE, 2011, 24 (02) :145-153

[30] Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions [J].

Rapoport, Natalya ;

Nam, Kweon-Ho ;

Gupta, Roohi ;

Gao, Zhongao ;

Mohan, Praveena ;

Payne, Allison ;

Todd, Nick ;

Liu, Xin ;

Kim, Taeho ;

Shea, Jill ;

Scaife, Courtney ;

Parker, Dennis L. ;

Jeong, Eun-Kee ;

Kennedy, Anne M. .

JOURNAL OF CONTROLLED RELEASE, 2011, 153 (01) :4-15

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