Evaluation of superparamagnetic iron oxide-polymer composite microcapsules for magnetic resonance-guided high-intensity focused ultrasound cancer surgery

被引：21

作者：

Sun, Yang ^{[1
]}

Zheng, Yuanyi ^{[1
]}

Li, Pan ^{[1
]}

Wang, Dong ^{[1
]}

Niu, Chengcheng ^{[1
]}

Gong, Yuping ^{[1
]}

Huang, Rongzhong ^{[1
]}

Wang, Zhibiao ^{[2
]}

Wang, Zhigang ^{[1
]}

Ran, Haitao ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing, Peoples R China

[2] Chongqing Med Univ, Coll Biomed Engn, Chongqing, Peoples R China

来源：

BMC CANCER | 2014年 / 14卷

关键词：

Cancer surgery; Hyperthermia; HIFU; MRI guidance; Iron oxide; Polymer; ABLATION; THERAPY; NANOPARTICLES; KIDNEY; TUMORS; LIVER;

D O I：

10.1186/1471-2407-14-800

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLGA-coated Fe3O4 microcapsules were combined with a magnetic resonance imaging-guided high-intensity focused ultrasound (MR-guided HIFU) platform, with the objective of investigating the effects of these composite microcapsules regarding MR-guided HIFU liver cancer surgery in vivo. Methods: PLGA-coated Fe3O4 microcapsules consisting of a liquid core and a PLGA-Fe3O4 shell were fabricated using a modified double emulsion evaporation method. Their acute biosafety was confirmed in vitro using MDA cells and in vivo using rabbits. To perform MR-guided HIFU surgery, the microcapsules were intravenously injected into a rabbit liver tumor model before MR-guided HIFU. T-2-weighted images and MR signal intensity in normal liver parenchyma and tumor tissue were acquired before and after injection, to assess the MR imaging ability of the microcapsules. After MR-guided HIFU ablation tissue temperature mapping, the coagulative volume and histopathology of the tumor tissue were analyzed to investigate the ablation effects of MR-guided HIFUs. Results: Scanning and transmission electron microscopy showed that the microcapsules displayed a spherical morphology and a shell-core structure (mean diameter, 587 nm). The hysteresis curve displayed the typical superparamagnetic properties of the microcapsules, which are critical to their application in MR-guided HIFU surgery. In MR-guided HIFU surgery, these microcapsules functioned as an MRI contrast agent, induced significant hyperthermal enhancement (P < 0.05) and significantly enhanced the volume of coagulative necrosis (P < 0.05). Conclusions: The administration of PLGA-coated Fe3O4 microcapsules is a potentially synergistic technique regarding the enhancement of MR-guided HIFU cancer surgery.

引用

页数：11

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