Single-molecule fluorescence studies of RNA: A decade's progress

被引：12

作者：

Karunatilaka, Krishanthi S. ^{[1
]}

Rueda, David ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CHEMICAL PHYSICS LETTERS | 2009年 / 476卷 / 1-3期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

RESONANCE ENERGY-TRANSFER; TERTIARY STRUCTURE FORMATION; II INTRON RIBOZYME; HAIRPIN RIBOZYME; FOLDING LANDSCAPE; TRANSITION-STATE; STRUCTURED RNA; GAAA TETRALOOP; RIBONUCLEASE-P; L1; STALK;

D O I：

10.1016/j.cplett.2009.06.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Over the past decade, single-molecule fluorescence studies have elucidated the structure-function relationship of RNA molecules. The real-time observation of individual RNAs by single-molecule fluorescence has unveiled the dynamic behavior of complex RNA systems in unprecedented detail, revealing the presence of transient intermediate states and their kinetic pathways. This review provides an overview of how single-molecule fluorescence has been used to explore the dynamics of RNA folding and catalysis. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1 / 10

页数：10

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